⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4445584 | 1.00 | TSHR (0.44) | — | |
| SCHEMBL8053585 | 1.00 | TSHR (0.44) | — | |
| SCHEMBL291758 | 1.00 | TSHR (0.44) | — | |
| SCHEMBL290865 | 1.00 | TSHR (0.44) | — | |
| SCHEMBL8379912 | 1.00 | TSHR (0.44) | — | |
| SCHEMBL292061 | 1.00 | TSHR (0.44) | — | |
| SCHEMBL8377210 | 1.00 | TSHR (0.44) | — | |
| SCHEMBL8374781 | 1.00 | TSHR (0.44) | — | |
| SCHEMBL8378823 | 1.00 | TSHR (0.44) | — | |
| SCHEMBL292459 | 1.00 | TSHR (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 153 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11364241-B2 | Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) | MEDIVATION TECHNOLOGIES LLC (US) | 2022-06-21 | — | — | US | disclosed |
| US-20210069191-A1 | DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | MEDIVATION TECHNOLOGIES LLC | 2021-03-11 | — | — | US | disclosed |
| US-10780088-B2 | Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) | MEDIVATION TECHNOLOGIES LLC (US) | 2020-09-22 | — | — | US | disclosed |
| US-20200261454-A1 | DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | MEDIVATION TECHNOLOGIES LLC | 2020-08-20 | — | — | US | disclosed |
| US-10543209-B2 | Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) | MEDIVATION TECHNOLOGIES LLC (US) | 2020-01-28 | — | — | US | disclosed |
| CN-110191911-A | Organic polymer functional group modification silica gel and its production technology and use | 湖北硒诺唯新功能化硅胶材料有限公司 | 2019-08-30 | — | — | CN | disclosed |
| US-20190176124-A1 | POLYORGANIC FUNCTIONAL GROUPS MODIFIED SILICA, PROCESSES TO MAKE AND USE THEREOF | SI-NOVATION LTD (CN) | 2019-06-13 | — | — | US | disclosed |
| US-20190070189-A1 | DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) FOR USE IN TREATMENT OF DISEASES ASSOCIATED WITH A PTEN DEFICIENCY | BIOMARIN PHARMACEUTICAL INC. | 2019-03-07 | — | — | US | disclosed |
| EP-3344683-A1 | POLYORGANIC FUNCTIONAL GROUPS MODIFIED SILICA, PROCESSES TO MAKE AND USE THEREOF | Si-Novation Ltd (CN) | 2018-07-11 | — | — | EP | disclosed |
| EP-2550266-B1 | HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION | AMITECH THERAPEUTICS SOLUTIONS INC (US) | 2018-05-09 | — | — | EP | disclosed |
| US-4760061-A | Antioestrogenic agent | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-07-26 | — | — | US | disclosed |
| EP-0161623-A2 | Polymeric battery separators | The B.F. GOODRICH Company (US) | 1985-11-21 | — | — | EP | disclosed |
| EP-0160508-A2 | Phenol derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-11-06 | — | — | EP | disclosed |
| US-4524104-A | ACRYLIC COPOLYMER AND BLOCKED ISOCYANATE | SANYO CHEMICAL INDUSTRIES, LTD. (JP) | 1985-06-18 | — | — | US | disclosed |
| US-4393070-A | HYPOTENSIVE, VASODILATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-07-12 | — | — | US | disclosed |
| US-4366236-A | HYDROQUINONE DERIVATIVE LAYER AND A WATER INSOLUBLE POLYMER | FUJI PHOTO FILM CO., LTD. (JP) | 1982-12-28 | — | — | US | disclosed |
| EP-0002756-B1 | UTILISATION OF TETRAZOLES AS STABILISERS FOR THERMOPLASTIC POLYMERS CONTAINING CHLORINE, AND STABILISED MOULDING COMPOSITIONS SO OBTAINED | CIBA-GEIGY AG (CH) | 1982-10-27 | — | — | EP | disclosed |
| US-4307103-A | TREATMENT OF HYPERTENSION AND CARDIOVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-12-22 | — | — | US | disclosed |
| US-4196110-A | CHLORINE CONTAINING THERMOPLASTIC, MONO- OR BISTETRAZOLE, HETA RESISTANCE | CIBA-GEIGY CORPORATION (US) | 1980-04-01 | — | — | US | disclosed |
| EP-0002756-A1 | Utilisation of tetrazoles as stabilisers for thermoplastic polymers containing chlorine, and stabilised moulding compositions so obtained | CIBA-GEIGY AG (CH) | 1979-07-11 | — | — | EP | disclosed |