Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19963631 | 0.90 | MKNK1 (0.36) | MKNK1KDM4EALDH1A1MAOAMAOB | |
| SCHEMBL19959021 | 0.79 | KDM4E (0.48) | MKNK1KDM4EALDH1A1MAOAMAOB | |
| SCHEMBL20234810 | 0.77 | MKNK1 (0.35) | MKNK1KDM4EALDH1A1 | |
| SCHEMBL18611618 | 0.76 | KDM4E (0.43) | MKNK1KDM4EALDH1A1MAOAMAOB | |
| SCHEMBL20234211 | 0.75 | KDM4E (0.38) | MKNK1KDM4EALDH1A1MAOAMAOB | |
| SCHEMBL24788343 | 0.75 | MAOB (0.41) | MKNK1MAOAMAOB | |
| SCHEMBL22005806 | 0.74 | KDM4E (0.36) | MKNK1KDM4EALDH1A1MAOAMAOB | |
| SCHEMBL22560613 | 0.71 | — | — | |
| SCHEMBL18591734 | 0.69 | KDM4E (0.43) | MKNK1KDM4EALDH1A1 | |
| SCHEMBL18611952 | 0.69 | LMNA (0.37) | MKNK1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230183209-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | ARVINAS OPERATIONS, INC. (US) | 2023-06-15 | — | — | US | disclosed |
| US-20180215731-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | ARVINAS OPERATIONS, INC. | 2018-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183209-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | CRBN, CBL, MDM2 | MKNK1 591/4885KDM4E 1613/4885ALDH1A1 3671/4885 |
| US-20180215731-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | CRBN, CBL, MDM2 | MKNK1 591/4885KDM4E 1613/4885ALDH1A1 3671/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.