Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.43 |
| ▸ | ARG1 | P05089 | 3/20 | 0.43 |
| ▸ | ARG2 | P78540 | 2/20 | 0.43 |
| ▸ | SPHK1 | Q9NYA1 | 5/20 | 0.43 |
| ▸ | RARB | P10826 | 4/20 | 0.43 |
| ▸ | SPHK2 | Q9NRA0 | 4/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | RARA | P10276 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12645530 | 0.81 | SPHK1 (0.46) | ALDH1A1SPHK1SPHK2 | |
| SCHEMBL13880925 | 0.80 | SPHK1 (0.43) | ALDH1A1S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL13880930 | 0.80 | SPHK1 (0.43) | ALDH1A1S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL588360 | 0.80 | SPHK1 (0.43) | ALDH1A1S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL13880923 | 0.80 | SPHK1 (0.43) | ALDH1A1S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL13880785 | 0.80 | SPHK1 (0.43) | ALDH1A1S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL25532846 | 0.80 | SPHK1 (0.43) | ALDH1A1S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL12588104 | 0.80 | SPHK1 (0.45) | ALDH1A1S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL12588108 | 0.80 | SPHK1 (0.45) | ALDH1A1S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL12588107 | 0.80 | SPHK1 (0.45) | ALDH1A1S1PR1S1PR3S1PR4S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960588-B2 | Benzyl cycloalkyl sphingosine 1-phosphate receptor modulators | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2011-06-14 | — | — | US | disclosed |
| US-20100249074-A1 | BENZYL-CYCLOALKYL SPHINGOSINE 1-PHOSPHATE RECEPTOR MODULATORS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2010-09-30 | — | — | US | disclosed |
| EP-2203409-A2 | BENZYL-CYCLOALKYL SPHINGOSINE 1-PHOSPHATE RECEPTOR MODULATORS | University Of Virginia Patent Foundation (US) | 2010-07-07 | — | — | EP | disclosed |
| WO-2009043013-A2 | BENZYL-CYCLOALKYL SPHINGOSINE 1-PHOSPHATE RECEPTOR MODULATORS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2009-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249074-A1 | BENZYL-CYCLOALKYL SPHINGOSINE 1-PHOSPHATE RECEPTOR MODULATORS | S1PR1, S1PR3, S1PR4 | ALDH1A1 3756/4885S1PR1 1/4885S1PR3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.