Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 10/20 | 0.43 |
| ▸ | SPHK2 | Q9NRA0 | 5/20 | 0.43 |
| ▸ | ESR1 | P03372 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.42 |
| ▸ | TACR2 | P21452 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SHBG | P04278 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25532846 | 1.00 | SPHK1 (0.43) | SPHK1SPHK2ESR1ADRA2AADORA3 | |
| SCHEMBL13880785 | 1.00 | SPHK1 (0.43) | SPHK1SPHK2ESR1ADRA2AADORA3 | |
| SCHEMBL13880925 | 1.00 | SPHK1 (0.43) | SPHK1SPHK2ESR1ADRA2AADORA3 | |
| SCHEMBL13880930 | 1.00 | SPHK1 (0.43) | SPHK1SPHK2ESR1ADRA2AADORA3 | |
| SCHEMBL13880923 | 1.00 | SPHK1 (0.43) | SPHK1SPHK2ESR1ADRA2AADORA3 | |
| SCHEMBL12645208 | 0.96 | SPHK1 (0.43) | SPHK1SPHK2ESR1ADRA2AADORA3 | |
| SCHEMBL12645214 | 0.96 | SPHK1 (0.43) | SPHK1SPHK2ESR1ADRA2AADORA3 | |
| SCHEMBL13880782 | 0.96 | SPHK1 (0.43) | SPHK1SPHK2ESR1ADRA2AADORA3 | |
| SCHEMBL12588101 | 0.95 | TNNC1 (0.43) | SPHK1SPHK2ESR1ADRA2AADORA3 | |
| SCHEMBL12645206 | 0.95 | TNNC1 (0.43) | SPHK1SPHK2ESR1ADRA2AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118298-A2 | COMPOSITIONS AND METHODS FOR BIOACTIVE COATINGS TO IMPROVE ALLOGRAFT INCORPORATION | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2010-10-14 | — | — | WO | claimed |
| EP-3054870-B1 | COMPRESSED BONE COMPOSITION AND METHODS OF USE THEREOF | LIFENET HEALTH (US) | 2023-08-16 | — | — | EP | disclosed |
| US-20230158205-A1 | COMPRESSED BONE COMPOSITION AND METHODS OF USE THEREOF | LIFENET HEALTH (US) | 2023-05-25 | — | — | US | disclosed |
| US-11576999-B2 | Compressed bone composition and methods of use thereof | LIFENET HEALTH (US) | 2023-02-14 | — | — | US | disclosed |
| US-20200368391-A1 | COMPRESSED BONE COMPOSITION AND METHODS OF USE THEREOF | TRUIST BANK | 2020-11-26 | — | — | US | disclosed |
| US-10780196-B2 | Compressed bone composition and methods of use thereof | LIFENET HEALTH (US) | 2020-09-22 | — | — | US | disclosed |
| US-10780196-B2 | Compressed bone composition and methods of use thereof | LIFENET HEALTH (US) | 2020-09-22 | — | — | US | disclosed |
| US-10220116-B2 | Liquefaction of bone matrix | LIFENET HEALTH (US) | 2019-03-05 | — | — | US | disclosed |
| US-9775931-B2 | Liquefaction of bone matrix | LIFENET HEALTH (US) | 2017-10-03 | — | — | US | disclosed |
| US-20160317709-A1 | LIQUEFACTION OF BONE MATRIX | TRUIST BANK | 2016-11-03 | — | — | US | disclosed |
| US-9345810-B2 | Liquefaction of bone matrix | LIFENET HEALTH (US) | 2016-05-24 | — | — | US | disclosed |
| US-20150010607-A1 | LIQUEFACTION OF BONE MATRIX | TRUIST BANK | 2015-01-08 | — | — | US | disclosed |
| WO-2013119873-A1 | LIQUEFACTION OF BONE MATRIX | LIFENET HEALTH (US) | 2013-08-15 | — | — | WO | disclosed |
| WO-2012129073-A2 | COMPOSITIONS AND METHODS FOR TISSUE ENGINEERING AND CELL BASED THERAPIES | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2012-09-27 | — | — | WO | disclosed |
| EP-2416767-A2 | COMPOSITIONS AND METHODS FOR BIOACTIVE COATINGS TO IMPROVE ALLOGRAFT INCORPORATION | University Of Virginia Patent Foundation (US) | 2012-02-15 | — | — | EP | disclosed |
| US-7960588-B2 | Benzyl cycloalkyl sphingosine 1-phosphate receptor modulators | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2011-06-14 | — | — | US | disclosed |
| WO-2010118298-A2 | COMPOSITIONS AND METHODS FOR BIOACTIVE COATINGS TO IMPROVE ALLOGRAFT INCORPORATION | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2010-10-14 | — | — | WO | disclosed |
| WO-2010118298-A2 | COMPOSITIONS AND METHODS FOR BIOACTIVE COATINGS TO IMPROVE ALLOGRAFT INCORPORATION | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2010-10-14 | — | — | WO | disclosed |
| US-20100249074-A1 | BENZYL-CYCLOALKYL SPHINGOSINE 1-PHOSPHATE RECEPTOR MODULATORS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2010-09-30 | — | — | US | disclosed |
| WO-2009043013-A2 | BENZYL-CYCLOALKYL SPHINGOSINE 1-PHOSPHATE RECEPTOR MODULATORS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2009-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10220116-B2 | Liquefaction of bone matrix | BMP2, BMP4, MATR3 | SPHK1 2528/4885SPHK2 2541/4885ESR1 2481/4885 |
| US-20150010607-A1 | LIQUEFACTION OF BONE MATRIX | BMP2, BMP4, MATR3 | SPHK1 2528/4885SPHK2 2541/4885ESR1 2481/4885 |
| US-20100249074-A1 | BENZYL-CYCLOALKYL SPHINGOSINE 1-PHOSPHATE RECEPTOR MODULATORS | S1PR1, S1PR3, S1PR4 | SPHK1 6/4885SPHK2 7/4885ESR1 2823/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.