SCHEMBL2044837 — predicted protein targets

Predicted protein targets (top 12)

	gene	UniProt	supporting neighbours	confidence
▸	PDE10A	Q9Y233	19/20	0.52

▸	KDM4E	B2RXH2	1/20	0.39

▸	ALDH1A1	P00352	1/20	0.39

▸	TP53	P04637	1/20	0.39

▸	MAPT	P10636	1/20	0.39

▸	PKM	P14618	1/20	0.39

▸	HPGD	P15428	1/20	0.39

▸	TSHR	P16473	1/20	0.39

▸	CASP1	P29466	1/20	0.39

▸	CASP7	P55210	1/20	0.39

▸	SMN1; SMN2	Q16637	1/20	0.39

▸	HSD17B10	Q99714	1/20	0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL2038211	0.90	PDE10A (0.56)	PDE10AKDM4EALDH1A1TP53MAPT
SCHEMBL2043214	0.83	PDE10A (0.50)	PDE10AKDM4E
SCHEMBL2053605	0.80	PDE10A (0.58)	PDE10A
SCHEMBL2036380	0.79	PDE10A (0.58)	PDE10AKDM4EALDH1A1MAPTHPGD
SCHEMBL2037381	0.78	PDE10A (0.62)	PDE10A
SCHEMBL2053542	0.77	PDE10A (0.59)	PDE10A
SCHEMBL2037872	0.77	PDE10A (0.48)	PDE10A
SCHEMBL2040973	0.75	PDE10A (0.57)	PDE10A
SCHEMBL2040370	0.75	PDE10A (0.63)	PDE10A
SCHEMBL2044926	0.75	PDE10A (0.59)	PDE10A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2011072695-A1	PHENYLIMIDAZOLE DERIVATIVES COMPRISING AN ETHYNYLENE LINKER AS PDE10A ENZYME INHIBITORS	H. LUNDBECK A/S (DK)	2011-06-23	—	—	WO	claimed
WO-2011072695-A1	PHENYLIMIDAZOLE DERIVATIVES COMPRISING AN ETHYNYLENE LINKER AS PDE10A ENZYME INHIBITORS	H. LUNDBECK A/S (DK)	2011-06-23	—	—	WO	disclosed