Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 4/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2048374 | 1.00 | MIF (0.40) | MIFITGB3ITGA2BHDAC6GLA | |
| SCHEMBL2046083 | 1.00 | MIF (0.40) | MIFITGB3ITGA2BHDAC6GLA | |
| SCHEMBL2784278 | 0.84 | ITGB3 (0.47) | ITGB3ITGA2BGLAGAAMEN1 | |
| SCHEMBL2784223 | 0.84 | ITGB3 (0.47) | ITGB3ITGA2BGLAGAAMEN1 | |
| SCHEMBL2786680 | 0.84 | ITGB3 (0.47) | ITGB3ITGA2BGLAGAAMEN1 | |
| SCHEMBL7073390 | 0.81 | GAA (0.42) | MIFHDAC6GLAGAAMEN1 | |
| SCHEMBL7057160 | 0.78 | ITGB3 (0.40) | ITGB3ITGA2BGLAGAAMEN1 | |
| SCHEMBL13048335 | 0.77 | MIF (0.46) | MIFHDAC6GLAGAAMEN1 | |
| SCHEMBL3411923 | 0.77 | MIF (0.46) | MIFHDAC6GLAGAAMEN1 | |
| SCHEMBL3413462 | 0.77 | MIF (0.46) | MIFHDAC6GLAGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2329821-A1 | Treatment of ocular neovascular disorders such as macular degeneration, angiod streaks, uveitis and macular edema | GlaxoSmithKline LLC (US) | 2011-06-08 | — | — | EP | disclosed |