Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 19/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.40 |
| ▸ | IKZF3 | Q9UKT9 | 5/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | IL1B | P01584 | 1/20 | 0.36 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20234966 | 0.85 | CRBN (0.52) | CRBNDDB1IKZF3BRD4TNF | |
| SCHEMBL20231817 | 0.84 | DDB1 (0.58) | CRBNDDB1 | |
| SCHEMBL20456510 | 0.83 | CRBN (0.42) | CRBNDDB1IKZF3IKZF1 | |
| SCHEMBL24132359 | 0.76 | CRBN (0.60) | CRBN | |
| SCHEMBL22609598 | 0.76 | CRBN (0.60) | CRBNIKZF1 | |
| SCHEMBL24132348 | 0.72 | CRBN (0.77) | CRBNDDB1IKZF3IKZF1 | |
| SCHEMBL24132063 | 0.72 | CRBN (0.44) | CRBNDDB1IKZF3BRD4TNF | |
| SCHEMBL20463302 | 0.70 | CRBN (0.46) | CRBNDDB1IKZF3BRD4TNF | |
| SCHEMBL24132363 | 0.70 | CRBN (0.63) | CRBNDDB1IKZF3BRD4TNF | |
| SCHEMBL24132354 | 0.70 | CRBN (0.61) | CRBNDDB1IKZF3BRD4TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018144649-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | Arvinas, Inc. (US) | 2018-08-09 | — | — | WO | disclosed |