Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 18/20 | 0.42 |
| ▸ | IKZF3 | Q9UKT9 | 5/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.39 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20231817 | 0.86 | DDB1 (0.58) | CRBNDDB1 | |
| SCHEMBL20234966 | 0.85 | CRBN (0.52) | CRBNIKZF3DDB1IKZF1 | |
| SCHEMBL20456236 | 0.83 | CRBN (0.40) | CRBNIKZF3DDB1IKZF1 | |
| SCHEMBL27231789 | 0.76 | CRBN (0.63) | CRBNCSNK1A1 | |
| SCHEMBL27223902 | 0.76 | CRBN (0.63) | CRBNCSNK1A1 | |
| SCHEMBL20120459 | 0.76 | CRBN (0.63) | CRBNIKZF1CSNK1A1 | |
| SCHEMBL25438464 | 0.74 | CRBN (0.52) | CRBNIKZF3CSNK1A1 | |
| SCHEMBL25429101 | 0.74 | CRBN (0.60) | CRBNCSNK1A1 | |
| SCHEMBL25334120 | 0.74 | CRBN (0.55) | CRBNDDB1 | |
| SCHEMBL22498026 | 0.72 | CRBN (0.77) | CRBNIKZF3DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018144649-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | Arvinas, Inc. (US) | 2018-08-09 | — | — | WO | disclosed |