Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | REN | P00797 | 2/20 | 0.33 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20456334 | 1.00 | KDM4E (0.34) | KDM4ERENCGASSMN1; SMN2NPC1 | |
| SCHEMBL20456137 | 0.84 | REN (0.33) | KDM4ERENSMN1; SMN2NPC1RAB9A | |
| SCHEMBL20456139 | 0.84 | REN (0.33) | KDM4ERENSMN1; SMN2NPC1RAB9A | |
| SCHEMBL20463491 | 0.84 | REN (0.33) | KDM4ERENSMN1; SMN2NPC1RAB9A | |
| SCHEMBL20456081 | 0.84 | REN (0.33) | KDM4ERENSMN1; SMN2NPC1RAB9A | |
| SCHEMBL19252777 | 0.80 | HTR2C (0.39) | CGASHPGDALDH1A1POLBL3MBTL1 | |
| SCHEMBL29613158 | 0.80 | HTR2C (0.39) | CGASHPGDALDH1A1POLBL3MBTL1 | |
| SCHEMBL20463810 | 0.76 | KDM4E (0.34) | KDM4ERENSMN1; SMN2NPC1RAB9A | |
| SCHEMBL20456329 | 0.76 | KDM4E (0.34) | KDM4ERENCGASSMN1; SMN2NPC1 | |
| SCHEMBL20485497 | 0.76 | REN (0.35) | KDM4ERENSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018144605-A1 | COMPOUNDS FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTION | GILEAD SCIENCES, INC. (US) | 2018-08-09 | — | — | WO | disclosed |