Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Econazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 1.00 |
| ▸ | USP2 | O75604 | 3/20 | 1.00 |
| ▸ | TP53 | P04637 | 3/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 3/20 | 1.00 |
| ▸ | HTT | P42858 | 3/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 3/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 1.00 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | NPY2R | P49146 | 2/20 | 1.00 |
| ▸ | GAA | P10253 | 2/20 | 1.00 |
| ▸ | RECQL | P46063 | 2/20 | 1.00 |
| ▸ | NPY1R | P25929 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Econazole SCHEMBL36214 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNAMEN1KMT2ATDP1 | |
| Econazole SCHEMBL36213 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNAMEN1KMT2ATDP1 | |
| Econazole SCHEMBL3692069 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNAMEN1KMT2ATDP1 | |
| Econazole SCHEMBL29379555 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNAMEN1KMT2ATDP1 | |
| Miconazole SCHEMBL8200081 | 0.95 | CYP3A4 (0.91) | CYP3A4LMNAMEN1KMT2ATDP1 | |
| Nitric Acid SCHEMBL11488271 | 0.93 | CYP3A4 (0.86) | CYP3A4LMNAMEN1KMT2ATDP1 | |
| Econazole SCHEMBL7602990 | 0.92 | IDO1 (1.00) | CYP3A4LMNAMEN1KMT2ATDP1 | |
| Econazole SCHEMBL20482166 | 0.92 | IDO1 (1.00) | CYP3A4LMNAMEN1KMT2ATDP1 | |
| Econazole SCHEMBL7602993 | 0.92 | IDO1 (1.00) | CYP3A4LMNAMEN1KMT2ATDP1 | |
| Econazole SCHEMBL34499 | 0.92 | IDO1 (1.00) | CYP3A4LMNAMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018144600-A1 | METHODS FOR TREATING FUNGAL INFECTIONS | CIDARA THERAPEUTICS, INC. (US) | 2018-08-09 | — | — | WO | disclosed |