Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 20/20 | 0.52 |
| ▸ | DDB1 | Q16531 | 18/20 | 0.52 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.52 |
| ▸ | TNF | P01375 | 1/20 | 0.52 |
| ▸ | IL1B | P01584 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL282871 | 0.86 | CRBN (0.70) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL26764344 | 0.86 | CRBN (0.70) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL29922128 | 0.86 | CRBN (0.70) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL20456403 | 0.84 | CRBN (0.74) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL26672081 | 0.84 | CRBN (0.53) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL29442250 | 0.77 | CRBN (0.54) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL15945432 | 0.77 | CRBN (0.54) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL15945434 | 0.77 | CRBN (0.54) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL29442254 | 0.77 | CRBN (0.54) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL21751056 | 0.76 | CRBN (0.52) | CRBNDDB1IKZF3TNFIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018144445-A1 | METHODS FOR TREATING HEMATOLOGICAL CANCER AND THE USE OF BIOMARKERS AS A PREDICTOR FOR RESPONSIVENESS TO TREATMENT COMPOUNDS | CELGENE CORPORATION (US) | 2018-08-09 | — | — | WO | disclosed |