Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.69 |
| ▸ | MEN1 | O00255 | 5/20 | 0.69 |
| ▸ | SLC40A1 | Q9NP59 | 3/20 | 0.66 |
| ▸ | CKS1B | P61024 | 7/20 | 0.64 |
| ▸ | SKP2 | Q13309 | 7/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | GFER | P55789 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | NMT1 | P30419 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | MITF | O75030 | 1/20 | 0.56 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17506522 | 0.90 | TDP1 (0.67) | TDP1KMT2AMEN1SLC40A1CKS1B | |
| SCHEMBL17506516 | 0.89 | SLC40A1 (0.82) | TDP1KMT2AMEN1SLC40A1CKS1B | |
| SCHEMBL26964293 | 0.83 | SLC40A1 (0.61) | TDP1KMT2AMEN1SLC40A1CKS1B | |
| SCHEMBL29800775 | 0.83 | SLC40A1 (0.61) | TDP1KMT2AMEN1SLC40A1CKS1B | |
| SCHEMBL17506520 | 0.83 | SLC40A1 (0.60) | TDP1KMT2AMEN1SLC40A1CKS1B | |
| SCHEMBL11973035 | 0.79 | SLC40A1 (1.00) | TDP1KMT2AMEN1SLC40A1CKS1B | |
| SCHEMBL30553465 | 0.78 | CKS1B (1.00) | TDP1KMT2AMEN1SLC40A1CKS1B | |
| SCHEMBL13633917 | 0.78 | CKS1B (1.00) | TDP1KMT2AMEN1SLC40A1CKS1B | |
| SCHEMBL14479869 | 0.78 | KMT2A (0.81) | TDP1KMT2AMEN1SLC40A1CKS1B | |
| SCHEMBL17506523 | 0.77 | CKS1B (1.00) | TDP1KMT2AMEN1SLC40A1CKS1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10040766-B2 | Ubiquitination inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2018-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10040766-B2 | Ubiquitination inhibitors | MDM2, RBX1, NEDD4 | TDP1 2023/4885KMT2A 501/4885MEN1 2624/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.