SCHEMBL20458068

SCHEMBL20458068

N#Cc1ccccc1ON

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.50
POLB P06746 1/20 0.50
SMN1; SMN2 Q16637 2/20 0.45
TSHR P16473 2/20 0.44
ALDH1A1 P00352 2/20 0.41
MAPK1 P28482 1/20 0.40
MAP4K4 O95819 1/20 0.40
IMPDH2 P12268 1/20 0.39
IMPDH1 P20839 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
HPGD P15428 1/20 0.39
AR P10275 2/20 0.39
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
HTR1A P08908 1/20 0.38
ADRA2A P08913 1/20 0.38
ADRA2B P18089 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7054403 0.80 GAA (0.64) GAAPOLBSMN1; SMN2TSHRALDH1A1
SCHEMBL8431375 0.78 GAA (0.62) GAAPOLBSMN1; SMN2TSHRALDH1A1
SCHEMBL104280 0.76 POLB (0.66) GAAPOLBSMN1; SMN2TSHRALDH1A1
SCHEMBL29518610 0.76 POLB (0.66) GAAPOLBSMN1; SMN2TSHRALDH1A1
SCHEMBL27495805 0.76 GAA (0.50) GAAPOLBSMN1; SMN2TSHRALDH1A1
SCHEMBL26509798 0.76 GAA (0.50) GAAPOLBSMN1; SMN2TSHRALDH1A1
SCHEMBL27960917 0.76 GAA (0.50) GAAPOLBSMN1; SMN2TSHRALDH1A1
SCHEMBL28906732 0.76 GAA (0.50) GAAPOLBSMN1; SMN2TSHRALDH1A1
SCHEMBL27455628 0.76 GAA (0.50) GAAPOLBSMN1; SMN2TSHRALDH1A1
SCHEMBL514487 0.76 GAA (0.50) GAAPOLBSMN1; SMN2TSHRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021024135-A1 AN IMPROVED PROCESS FOR PREPARATION OF METHYL (2E)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE COROMANDEL INTERNATIONAL LIMITED (IN) 2021-02-11 WO disclosed
EP-2998299-B1 PREPARATION METHOD OF AZOXYSTROBIN NUTRICHEM COMPANY LTD (CN) 2018-08-08 EP disclosed