Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 5/20 | 0.35 |
| ▸ | CASP7 | P55210 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15906809 | 0.86 | TAAR1 (0.37) | TAAR1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL14317457 | 0.86 | TAAR1 (0.37) | TAAR1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL14251550 | 0.86 | TAAR1 (0.37) | TAAR1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL14318088 | 0.82 | HRH4 (0.41) | ALDH1A1HRH4KITPRKCQPRKCD | |
| SCHEMBL14318090 | 0.76 | OPRK1 (0.39) | KDM4EALDH1A1HSD17B10ALOX15HPGD | |
| SCHEMBL14315366 | 0.75 | HRH4 (0.35) | KDM4EALDH1A1MEN1KMT2AHRH4 | |
| SCHEMBL15906811 | 0.75 | KIT (0.36) | HRH4KITPRKCQPRKCDPRKCI | |
| SCHEMBL29654298 | 0.74 | PDE10A (0.46) | TAAR1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL14251040 | 0.73 | PRKCQ (0.34) | TAAR1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL14251042 | 0.73 | PRKCQ (0.34) | TAAR1KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2721019-B1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE | AGIOS PHARMACEUTICALS INC (US) | 2018-08-08 | — | — | EP | disclosed |