Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | IDH1 | O75874 | 10/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14251107 | 1.00 | RET (0.44) | RETIDH1NR1H2NR1H3GPR119 | |
| SCHEMBL14251331 | 0.86 | RET (0.43) | RETIDH1NR1H2NR1H3GPR119 | |
| SCHEMBL14251333 | 0.86 | RET (0.43) | RETIDH1NR1H2NR1H3GPR119 | |
| SCHEMBL14251565 | 0.84 | IDH1 (0.43) | IDH1 | |
| SCHEMBL14315321 | 0.84 | IDH1 (0.43) | IDH1 | |
| SCHEMBL14251439 | 0.84 | RET (0.42) | RETIDH1NR1H2NR1H3GPR119 | |
| SCHEMBL14250774 | 0.84 | RET (0.42) | RETIDH1NR1H2NR1H3GPR119 | |
| SCHEMBL14250416 | 0.83 | IDH1 (0.46) | RETIDH1NR1H2NR1H3GPR119 | |
| SCHEMBL14250414 | 0.83 | IDH1 (0.46) | RETIDH1NR1H2NR1H3GPR119 | |
| SCHEMBL20458563 | 0.83 | IDH1 (0.39) | IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2721019-B1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE | AGIOS PHARMACEUTICALS INC (US) | 2018-08-08 | — | — | EP | disclosed |