SCHEMBL20458647

SCHEMBL20458647

CC12CCC(NC(=O)OCCN3CCOCC3)CC1CCC1C2CCC2(C)C(c3ccc(=O)oc3)CCC12O

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATP1A1 P05023 11/20 0.60
ATP1B1 P05026 11/20 0.60
ATP1A3 P13637 11/20 0.60
ATP1B2 P14415 11/20 0.60
ATP1A2 P50993 11/20 0.60
ATP1B3 P54709 11/20 0.60
FXYD2 P54710 11/20 0.60
ATP1A4 Q13733 11/20 0.60
CYP3A4 P08684 3/20 0.60
CYP3A5 P20815 2/20 0.60
AR P10275 1/20 0.60
ZFP91 Q96JP5 1/20 0.60
CYP3A7 P24462 1/20 0.54
STAT3 P40763 1/20 0.45
NPC1 O15118 3/20 0.41
RAB9A P51151 3/20 0.41
PAX8 Q06710 2/20 0.41
LMNA P02545 2/20 0.41
TP53 P04637 2/20 0.41
TSHR P16473 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15605720 1.00 ATP1A1 (0.60) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
SCHEMBL29550567 0.95 ATP1A1 (0.61) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
SCHEMBL15527182 0.94 ATP1A1 (0.60) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
SCHEMBL15527139 0.93 ATP1A1 (0.59) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
SCHEMBL29550842 0.92 ATP1A1 (0.61) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
SCHEMBL29550183 0.90 ATP1A1 (0.55) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
SCHEMBL15527988 0.90 ATP1A1 (0.66) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
SCHEMBL15527478 0.90 ATP1A1 (0.60) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
SCHEMBL15527097 0.89 ATP1A1 (0.63) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2
SCHEMBL29550129 0.89 ATP1A1 (0.65) ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3453713-B1 BUFADIENOLIDE COMPOUNDS SUBSTITUTED IN POSITION 3 BY AN AMINE GROUP FOR USE IN THE TREATMENT OF CANCER NEUPHARMA INC (US) 2021-09-08 EP disclosed
EP-2852285-B1 BUFADIENOLIDE COMPOUNDS SUBSTITUTED IN POSITION 3 BY A HETEROCYCLIC AMINE FOR USE IN THE TREATMENT OF CANCER NEUPHARMA INC (US) 2018-08-08 EP disclosed