Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Prednisone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 4/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 10/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | PGR | P06401 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | SERPINA6 | P08185 | 4/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.68 |
| ▸ | AR | P10275 | 2/20 | 0.68 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.68 |
| ▸ | TNF | P01375 | 1/20 | 0.68 |
| ▸ | IL6 | P05231 | 1/20 | 0.68 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.68 |
| ▸ | GLUL | P15104 | 1/20 | 0.68 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Prednisone SCHEMBL3408330 | 1.00 | HSD17B10 (1.00) | HSD17B10NR3C1HIF1ALMNAKMT2A | |
| Prednisone SCHEMBL15304738 | 1.00 | HSD17B10 (1.00) | HSD17B10NR3C1HIF1ALMNAKMT2A | |
| Prednisone SCHEMBL1236044 | 1.00 | HSD17B10 (1.00) | HSD17B10NR3C1HIF1ALMNAKMT2A | |
| Prednisone SCHEMBL8262569 | 1.00 | HSD17B10 (1.00) | HSD17B10NR3C1HIF1ALMNAKMT2A | |
| Prednisone SCHEMBL13620924 | 1.00 | HSD17B10 (1.00) | HSD17B10NR3C1HIF1ALMNAKMT2A | |
| Prednisone SCHEMBL13323411 | 1.00 | HSD17B10 (1.00) | HSD17B10NR3C1HIF1ALMNAKMT2A | |
| Prednisone SCHEMBL23974933 | 1.00 | HSD17B10 (1.00) | HSD17B10NR3C1HIF1ALMNAKMT2A | |
| Prednisone SCHEMBL21281533 | 1.00 | HSD17B10 (1.00) | HSD17B10NR3C1HIF1ALMNAKMT2A | |
| Prednisone SCHEMBL21883168 | 1.00 | HSD17B10 (1.00) | HSD17B10NR3C1HIF1ALMNAKMT2A | |
| Prednisone SCHEMBL5572169 | 1.00 | HSD17B10 (1.00) | HSD17B10NR3C1HIF1ALMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3527210-B1 | COMBINED COMPOSITION COMPRISING A BENZOHETEROCYCLIC COMPOUND AND AN ANDROGEN RECEPTOR PATHWAY MODULATOR AND USES THEREOF | KANGPU BIOPHARMACEUTICALS LTD (CN) | 2021-06-09 | — | — | EP | disclosed |
| EP-3357513-A1 | PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | Kangpu Biopharmaceuticals, Ltd. (CN) | 2018-08-08 | — | — | EP | disclosed |