Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Prednisone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 4/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 10/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | PGR | P06401 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | SERPINA6 | P08185 | 4/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.68 |
| ▸ | AR | P10275 | 2/20 | 0.68 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.68 |
| ▸ | TNF | P01375 | 1/20 | 0.68 |
| ▸ | IL6 | P05231 | 1/20 | 0.68 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.68 |
| ▸ | GLUL | P15104 | 1/20 | 0.68 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Prednisone SCHEMBL3408330 | 1.00 | HSD17B10 (1.00) | HSD17B10NR3C1HIF1ALMNAKMT2A | |
| Prednisone SCHEMBL15304738 | 1.00 | HSD17B10 (1.00) | HSD17B10NR3C1HIF1ALMNAKMT2A | |
| Prednisone SCHEMBL1236044 | 1.00 | HSD17B10 (1.00) | HSD17B10NR3C1HIF1ALMNAKMT2A | |
| Prednisone SCHEMBL8262569 | 1.00 | HSD17B10 (1.00) | HSD17B10NR3C1HIF1ALMNAKMT2A | |
| Prednisone SCHEMBL13620924 | 1.00 | HSD17B10 (1.00) | HSD17B10NR3C1HIF1ALMNAKMT2A | |
| Prednisone SCHEMBL13323411 | 1.00 | HSD17B10 (1.00) | HSD17B10NR3C1HIF1ALMNAKMT2A | |
| Prednisone SCHEMBL23974933 | 1.00 | HSD17B10 (1.00) | HSD17B10NR3C1HIF1ALMNAKMT2A | |
| Prednisone SCHEMBL20459224 | 1.00 | HSD17B10 (1.00) | HSD17B10NR3C1HIF1ALMNAKMT2A | |
| Prednisone SCHEMBL21281533 | 1.00 | HSD17B10 (1.00) | HSD17B10NR3C1HIF1ALMNAKMT2A | |
| Prednisone SCHEMBL21883168 | 1.00 | HSD17B10 (1.00) | HSD17B10NR3C1HIF1ALMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070014719-A1 | Steroid analogs and characterization and treatment methods | BIOVIE INC. | 2007-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070014719-A1 | Steroid analogs and characterization and treatment methods | CYP17A1, HSD17B11, HSD3B1 | NR3C1 30/4885HSD17B10 90/4885HIF1A 567/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.