Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 3/20 | 0.58 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.58 |
| ▸ | CDK2 | P24941 | 10/20 | 0.57 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.57 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.57 |
| ▸ | JUN | P05412 | 3/20 | 0.57 |
| ▸ | IGF1R | P08069 | 13/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.45 |
| ▸ | INSR | P06213 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31500952 | 0.87 | CDK2 (0.53) | MAPK10IRAK4CDK2MAPK8MAPK9 | |
| SCHEMBL22228694 | 0.84 | CDK2 (0.62) | MAPK10IRAK4CDK2MAPK8MAPK9 | |
| SCHEMBL22228710 | 0.84 | MAPK8 (0.53) | MAPK10IRAK4CDK2MAPK8MAPK9 | |
| SCHEMBL20468460 | 0.83 | CDK2 (0.56) | MAPK10IRAK4CDK2MAPK8MAPK9 | |
| SCHEMBL31500965 | 0.83 | CDK2 (0.56) | MAPK10IRAK4CDK2MAPK8MAPK9 | |
| SCHEMBL20455526 | 0.82 | CDK2 (0.58) | MAPK10IRAK4CDK2MAPK8MAPK9 | |
| SCHEMBL31500996 | 0.82 | CDK2 (0.58) | MAPK10IRAK4CDK2MAPK8MAPK9 | |
| SCHEMBL22228853 | 0.81 | CDK2 (0.59) | MAPK10IRAK4CDK2MAPK8MAPK9 | |
| SCHEMBL31500962 | 0.81 | CDK2 (0.59) | MAPK10IRAK4CDK2MAPK8MAPK9 | |
| SCHEMBL22228927 | 0.81 | CDK2 (0.51) | MAPK10IRAK4CDK2MAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3577116-B1 | DERIVATIVES OF N-CYCLOALKYL/HETEROCYCLOALKYL-4-(IMIDAZO[1,2-A]PYRIDINE)PYRIMIDIN-2-AMINE AS THERAPEUTIC AGENTS | CHANGZHOU QIANHONG BIO PHARMA CO LTD (CN) | 2025-04-23 | — | — | EP | disclosed |
| US-11111245-B2 | Derivatives of N-cycloalkyl/heterocycloalkyl-4-(imidazo[1,2-a]pyridine)pyrimidin-2-amine as therapeutic agents | AUCENTRA THERAPEUTICS PTY LTD (AU) | 2021-09-07 | — | — | US | disclosed |
| US-11111245-B2 | Derivatives of N-cycloalkyl/heterocycloalkyl-4-(imidazo[1,2-a]pyridine)pyrimidin-2-amine as therapeutic agents | AUCENTRA THERAPEUTICS PTY LTD (AU) | 2021-09-07 | — | — | US | disclosed |
| US-20200231586-A1 | DERIVATIVES OF N-CYCLOALKYL/HETEROCYCLOALKYL-4-(IMIDAZO[1,2-a]PYRIDINE)PYRIMIDIN-2-AMINE AS THERAPEUTIC AGENTS | AUCENTRA THERAPEUTICS PTY LTD (AU) | 2020-07-23 | — | — | US | disclosed |
| US-20200231586-A1 | DERIVATIVES OF N-CYCLOALKYL/HETEROCYCLOALKYL-4-(IMIDAZO[1,2-a]PYRIDINE)PYRIMIDIN-2-AMINE AS THERAPEUTIC AGENTS | AUCENTRA THERAPEUTICS PTY LTD (AU) | 2020-07-23 | — | — | US | disclosed |
| WO-2018141002-A2 | DERIVATIVES OF N-CYCLOALKYL/HETEROCYCLOALKYL-4-(IMIDAZO [1,2-a]PYRIDINE)PYRIMIDIN-2-AMINE AS THERAPEUTIC AGENTS | UNIVERSITY OF SOUTH AUSTRALIA (AU) | 2018-08-09 | — | — | WO | disclosed |
| WO-2018141002-A2 | DERIVATIVES OF N-CYCLOALKYL/HETEROCYCLOALKYL-4-(IMIDAZO [1,2-a]PYRIDINE)PYRIMIDIN-2-AMINE AS THERAPEUTIC AGENTS | UNIVERSITY OF SOUTH AUSTRALIA (AU) | 2018-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200231586-A1 | DERIVATIVES OF N-CYCLOALKYL/HETEROCYCLOALKYL-4-(IMIDAZO[1,2-a]PYRIDINE)PYRIMIDIN-2-AMINE AS THERAPEUTIC AGENTS | CDK2, CDKL1, CDKL2 | MAPK10 411/4885IRAK4 1097/4885CDK2 1/4885 |
| US-11111245-B2 | Derivatives of N-cycloalkyl/heterocycloalkyl-4-(imidazo[1,2-a]pyridine)pyrimidin-2-amine as therapeutic agents | CDK2, CDKL1, CDKL2 | MAPK10 411/4885IRAK4 1097/4885CDK2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.