Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 15/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | CD69 | Q07108 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.40 |
| ▸ | CDKL2 | Q92772 | 1/20 | 0.40 |
| ▸ | RIOK1 | Q9BRS2 | 1/20 | 0.40 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.40 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20461005 | 0.90 | BTK (0.52) | BTKJAK2CYP3A4HRH2CDK7 | |
| SCHEMBL20053910 | 0.90 | BTK (0.52) | BTKJAK2CYP3A4HRH2CDK7 | |
| SCHEMBL20461218 | 0.83 | BTK (0.40) | BTKJAK2CYP3A4HRH2CDK7 | |
| SCHEMBL20053904 | 0.80 | BTK (0.51) | BTK | |
| SCHEMBL20461147 | 0.79 | BTK (0.49) | BTKJAK2CYP3A4HRH2CDK7 | |
| SCHEMBL20053966 | 0.79 | BTK (0.52) | BTKJAK2CYP3A4HRH2CDK7 | |
| SCHEMBL20461100 | 0.77 | BTK (0.47) | BTKJAK2CYP3A4HRH2CDK7 | |
| SCHEMBL20461116 | 0.77 | BTK (0.61) | BTKJAK2CYP3A4HRH2CDK7 | |
| SCHEMBL20053961 | 0.76 | MAPK1 (0.40) | BTKJAK2CDK7CCNT1CCNA2 | |
| SCHEMBL20053949 | 0.75 | BTK (0.47) | BTKJAK2CYP3A4HRH2CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3357921-A2 | BIARYL COMPOUNDS USEFUL FOR THE TREATMENT OF HUMAN DISEASES IN ONCOLOGY, NEUROLOGY AND IMMUNOLOGY | Sunesis Pharmaceuticals, Inc. (US) | 2018-08-08 | — | — | EP | disclosed |