Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | WNT1 | P04628 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 10/20 | 0.33 |
| ▸ | HTR7 | P34969 | 10/20 | 0.33 |
| ▸ | DRD2 | P14416 | 3/20 | 0.32 |
| ▸ | HTR6 | P50406 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20325149 | 0.92 | KDM1A (0.45) | KDM1ASLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL12395763 | 0.81 | KDM1A (0.46) | KDM1AHTR1AHTR7 | |
| SCHEMBL18611442 | 0.81 | KDM1A (0.36) | KDM1AHTR1AHTR7DRD2HTR6 | |
| SCHEMBL18591842 | 0.80 | KCNH2 (0.42) | KDM1AHTR1AHTR7 | |
| SCHEMBL18551074 | 0.80 | HTR1A (0.33) | KDM1AHTR1AHTR7 | |
| SCHEMBL24060967 | 0.80 | KDM1A (0.51) | KDM1ASLC6A2SLC6A4SLC6A3WNT1 | |
| SCHEMBL21025868 | 0.79 | CYP2D6 (0.40) | KDM1AHTR1AHTR7 | |
| SCHEMBL23695901 | 0.78 | KDM1A (0.32) | KDM1AHTR1AHTR7 | |
| SCHEMBL18591791 | 0.77 | GBA2 (0.34) | KDM1AHTR1AHTR7 | |
| SCHEMBL21472200 | 0.76 | KDM1A (0.35) | KDM1AHTR1AHTR7DRD2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018144649-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | Arvinas, Inc. (US) | 2018-08-09 | — | — | WO | disclosed |