SCHEMBL2046372

SCHEMBL2046372

Oc1cc(Cl)nnc1Oc1ccccc1-c1nc2ccccc2o1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 2/20 0.52
KDM6B O15054 1/20 0.49
KDM6A O15550 1/20 0.49
TOP2A P11388 1/20 0.47
AGPAT2 O15120 2/20 0.47
MAPT P10636 9/20 0.46
KDM4E B2RXH2 5/20 0.46
ALDH1A1 P00352 5/20 0.46
HPGD P15428 3/20 0.42
USP2 O75604 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
TP53 P04637 4/20 0.41
NPC1 O15118 4/20 0.41
RAB9A P51151 3/20 0.41
THRB P10828 2/20 0.41
CASP3 P42574 1/20 0.41
SENP8 Q96LD8 1/20 0.41
SENP7 Q9BQF6 1/20 0.41
SENP6 Q9GZR1 1/20 0.41
HSD17B10 Q99714 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2051550 0.77 NCOA1 (0.40) PTGS2MAPTKDM4EALDH1A1HPGD
SCHEMBL2046732 0.75 KMT2A (0.53) MAPTKDM4EALDH1A1HPGDTDP1
SCHEMBL2048850 0.74 TP53 (0.42) MAPTKDM4EALDH1A1HPGDTP53
SCHEMBL19972045 0.74 ELANE (0.59) PTGS2KDM6BKDM6ATOP2AMAPT
SCHEMBL2047260 0.73 LMNA (0.46) MAPTALDH1A1HPGDRAB9AMEN1
SCHEMBL31048510 0.73 C1R (0.64) PTGS2TOP2AMAPTKDM4EALDH1A1
SCHEMBL13495717 0.73 C1R (0.64) PTGS2TOP2AMAPTKDM4EALDH1A1
SCHEMBL2048834 0.73 ELANE (0.36) MAPTKDM4EALDH1A1HPGDTP53
SCHEMBL2050924 0.73 CGAS (0.42) TOP2AAGPAT2MAPTALDH1A1TP53
SCHEMBL8035668 0.73 TOP2A (0.79) PTGS2KDM6BKDM6ATOP2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7964531-B2 3-phenoxy-4-pyridazinol derivatives and herbicidal composition containing the same MITSUI CHEMICALS AGRO, INC. (JP) 2011-06-21 US disclosed
US-20100041555-A1 3-Phenoxy-4-pyridazinol derivatives and herbicidal composition containing the same MITSUI CHEMICALS AGRO, INC. (JP) 2010-02-18 US disclosed
US-7608563-B2 3-phenoxy-4-pyridazinol derivatives and herbicide composition containing the same MITSUI AGRO CHEMICALS, INC. (JP) 2009-10-27 US disclosed
EP-1426365-B9 3-PHENOXY-4-PYRIDAZINOL DERIVATIVE AND HERBICIDE COMPOSITION CONTAINING THE SAME MITSUI CHEMICALS AGRO INC (JP) 2009-10-21 EP disclosed
EP-1426365-B1 3-PHENOXY-4-PYRIDAZINOL DERIVATIVE AND HERBICIDE COMPOSITION CONTAINING THE SAME SANKYO AGRO CO LTD (JP) 2009-07-15 EP disclosed
US-20050037925-A1 3-phenoxy-4-pyridazinol derivatives and herbicide composition containing the same SANKYO AGRO COMPANY, LIMITED (JP) 2005-02-17 US disclosed
EP-1426365-A1 3-PHENOXY-4-PYRIDAZINOL DERIVATIVE AND HERBICIDE COMPOSITION CONTAINING THE SAME Sankyo Agro Company, Limited (JP) 2004-06-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100041555-A1 3-Phenoxy-4-pyridazinol derivatives and herbicidal composition containing the same CBR3, DDT, CBR1 PTGS2 1573/4885KDM6B 1181/4885KDM6A 1519/4885
US-20050037925-A1 3-phenoxy-4-pyridazinol derivatives and herbicide composition containing the same CBR3, DDT, CHRM2 PTGS2 1589/4885KDM6B 1125/4885KDM6A 1431/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.