Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20471994 | 0.99 | HSD17B10 (0.46) | HSD17B10PTGDR2KDM4EALDH1A1HSP90AA1 | |
| SCHEMBL20471949 | 0.96 | HSD17B10 (0.48) | HSD17B10PTGDR2KDM4EALDH1A1HSP90AA1 | |
| SCHEMBL16997485 | 0.92 | HSD17B10 (0.49) | HSD17B10PTGDR2KDM4EALDH1A1HSP90AA1 | |
| SCHEMBL20471958 | 0.89 | TDP1 (0.43) | HSD17B10KDM4EALDH1A1HSP90AA1MAPT | |
| SCHEMBL2772497 | 0.86 | SMN1; SMN2 (0.49) | HSD17B10PTGDR2KDM4EALDH1A1HSP90AA1 | |
| SCHEMBL17959008 | 0.84 | TDP1 (0.44) | HSD17B10KDM4EALDH1A1HSP90AA1MAPT | |
| SCHEMBL22176359 | 0.84 | MAPT (0.59) | HSD17B10KDM4EALDH1A1HSP90AA1MAPT | |
| SCHEMBL4600210 | 0.84 | HPGD (0.51) | HSD17B10PTGDR2KDM4EALDH1A1HSP90AA1 | |
| Hydrochloric Acid SCHEMBL22164224 | 0.83 | MAPT (0.57) | HSD17B10KDM4EALDH1A1HSP90AA1MAPT | |
| SCHEMBL22175914 | 0.83 | MAPT (0.50) | KDM4EALDH1A1HSP90AA1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3580224-B1 | ASK1 INHIBITING AGENTS | BIOGEN MA INC (US) | 2022-07-13 | — | — | EP | disclosed |
| EP-3580224-B1 | ASK1 INHIBITING AGENTS | BIOGEN MA INC (US) | 2022-07-13 | — | — | EP | disclosed |
| US-11168095-B2 | ASK1 inhibiting agents | BIOGEN MA INC. (US) | 2021-11-09 | — | — | US | disclosed |
| US-11168095-B2 | ASK1 inhibiting agents | BIOGEN MA INC. (US) | 2021-11-09 | — | — | US | disclosed |
| WO-2018148204-A1 | ASK1 INHIBITING AGENTS | BIOGEN MA INC. (US) | 2018-08-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11168095-B2 | ASK1 inhibiting agents | MAP3K1, MAP3K10, MAP3K20 | HSD17B10 2945/4885PTGDR2 4066/4885KDM4E 2991/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.