Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 19/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1008190 | 0.79 | LTA4H (0.71) | LTA4HKCNH2 | |
| SCHEMBL1008080 | 0.79 | LTA4H (0.57) | LTA4HKCNH2 | |
| SCHEMBL1008432 | 0.75 | LTA4H (0.58) | LTA4HKCNH2 | |
| Hydrochloric Acid SCHEMBL2030751 | 0.75 | LTA4H (0.57) | LTA4HKCNH2 | |
| SCHEMBL12356761 | 0.74 | LTA4H (0.63) | LTA4HKCNH2 | |
| SCHEMBL1061860 | 0.73 | LTA4H (0.58) | LTA4HKCNH2 | |
| SCHEMBL1008982 | 0.72 | DRD3 (0.60) | LTA4HKCNH2 | |
| SCHEMBL1891389 | 0.72 | LTA4H (0.76) | LTA4HKCNH2ESR1ESR2 | |
| SCHEMBL1888396 | 0.71 | LTA4H (1.00) | LTA4HKCNH2 | |
| SCHEMBL1008996 | 0.69 | LTA4H (0.63) | LTA4HKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2336125-A1 | Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase | Janssen Pharmaceutica N.V. (BE) | 2011-06-22 | — | — | EP | disclosed |