Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 known ✓ | O60674 | 14/20 | 0.93 |
| ▸ | JAK1 known ✓ | P23458 | 11/20 | 0.93 |
| ▸ | JAK3 known ✓ | P52333 | 5/20 | 0.93 |
| ▸ | TYK2 known ✓ | P29597 | 2/20 | 0.93 |
| ▸ | FGFR1 known ✓ | P11362 | 2/20 | 0.83 |
| ▸ | KIT known ✓ | P10721 | 1/20 | 0.83 |
| ▸ | KDR known ✓ | P35968 | 1/20 | 0.59 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.83 |
| ▸ | PAK4 | O96013 | 2/20 | 0.83 |
| ▸ | ABL1 | P00519 | 2/20 | 0.83 |
| ▸ | RET | P07949 | 2/20 | 0.83 |
| ▸ | LTK | P29376 | 2/20 | 0.83 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.83 |
| ▸ | CLK2 | P49760 | 2/20 | 0.83 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.83 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.83 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.83 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.83 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.83 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid SCHEMBL3001694 | 1.00 | JAK2 (0.93) | JAK2JAK1JAK3TYK2DAPK3 | |
| Ruxolitinib SCHEMBL31073616 | 0.96 | JAK2 (1.00) | JAK2JAK1JAK3TYK2DAPK3 | |
| Ruxolitinib SCHEMBL1369365 | 0.96 | JAK2 (1.00) | JAK2JAK1JAK3TYK2DAPK3 | |
| Ruxolitinib SCHEMBL29357426 | 0.96 | JAK2 (1.00) | JAK2JAK1JAK3TYK2DAPK3 | |
| Ruxolitinib SCHEMBL1371422 | 0.96 | JAK2 (1.00) | JAK2JAK1JAK3TYK2DAPK3 | |
| Ruxolitinib SCHEMBL29677819 | 0.96 | JAK2 (1.00) | JAK2JAK1JAK3TYK2DAPK3 | |
| SCHEMBL98692 | 0.94 | JAK2 (0.92) | JAK2JAK1JAK3TYK2DAPK3 | |
| SCHEMBL3008701 | 0.94 | JAK2 (0.92) | JAK2JAK1JAK3TYK2DAPK3 | |
| Deuruxolitinib SCHEMBL29398377 | 0.91 | JAK2 (0.81) | JAK2JAK1JAK3TYK2DAPK3 | |
| SCHEMBL2250179 | 0.91 | JAK2 (0.96) | JAK2JAK1JAK3TYK2DAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10975085-B2 | Process for preparing a composition comprising an enantiomeric excess of greater than or equal to 90% of the (R)-enantiomer of a compound of formula III | INCYTE HOLDINGS CORPORATION (US) | 2021-04-13 | — | — | US | disclosed |
| US-10364248-B2 | Processes for preparing 4-chloro-7H-pyrrolo[2,3-d]pyrimidine | INCYTE CORPORATION (US) | 2019-07-30 | — | — | US | disclosed |
| US-20180237442-A1 | PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS | INCYTE CORPORATION | 2018-08-23 | — | — | US | disclosed |
| CN-105669676-A | Processes for preparing jak inhibitors and related intermediate compounds | 因西特控股公司 | 2016-06-15 | — | — | CN | disclosed |
| CN-105669675-A | Processes for preparing jak inhibitors and related intermediate compounds | 因西特控股公司 | 2016-06-15 | — | — | CN | disclosed |
| CN-102348693-B | Methods for preparing JAK inhibitors and related intermediate compounds | INCYTE CORP. (US) | 2016-03-16 | — | — | CN | disclosed |
| CN-102348693-A | Methods for preparing JAK inhibitors and related intermediate compounds | INCYTE CORP | 2012-02-08 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10975085-B2 | Process for preparing a composition comprising an enantiomeric excess of greater than or equal to 90% of the (R)-enantiomer of a compound of formula III | JAK1, JAK3, JAK2 | JAK2 3/4885JAK1 1/4885JAK3 2/4885 |
| US-10364248-B2 | Processes for preparing 4-chloro-7H-pyrrolo[2,3-d]pyrimidine | JAK1, JAK3, JAK2 | JAK2 3/4885JAK1 1/4885JAK3 2/4885 |
| US-20180237442-A1 | PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS | JAK3, JAK1, JAK2 | JAK2 3/4885JAK1 2/4885JAK3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.