Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 20/20 | 0.84 |
| ▸ | BMPR1B | O00238 | 3/20 | 0.81 |
| ▸ | CDC7 | O00311 | 3/20 | 0.81 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.81 |
| ▸ | PLK4 | O00444 | 3/20 | 0.81 |
| ▸ | CIT | O14578 | 3/20 | 0.81 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.81 |
| ▸ | IKBKB | O14920 | 3/20 | 0.81 |
| ▸ | CASK | O14936 | 3/20 | 0.81 |
| ▸ | AURKA | O14965 | 3/20 | 0.81 |
| ▸ | GAK | O14976 | 3/20 | 0.81 |
| ▸ | MAST4 | O15021 | 3/20 | 0.81 |
| ▸ | CHUK | O15111 | 3/20 | 0.81 |
| ▸ | MUSK | O15146 | 3/20 | 0.81 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.81 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.81 |
| ▸ | MAP3K13 | O43283 | 3/20 | 0.81 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.81 |
| ▸ | MAP3K7 | O43318 | 3/20 | 0.81 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20477265 | 0.95 | RIPK1 (0.86) | RIPK1BMPR1BCDC7PIK3CDPLK4 | |
| SCHEMBL20477276 | 0.91 | RIPK1 (1.00) | RIPK1BMPR1BCDC7PIK3CDPLK4 | |
| Tp-030N SCHEMBL20477267 | 0.90 | RIPK1 (1.00) | RIPK1BMPR1BCDC7PIK3CDPLK4 | |
| SCHEMBL20477343 | 0.89 | RIPK1 (0.93) | RIPK1BMPR1BCDC7PIK3CDPLK4 | |
| SCHEMBL20477231 | 0.88 | RIPK1 (1.00) | RIPK1BMPR1BCDC7PIK3CDPLK4 | |
| SCHEMBL20477363 | 0.88 | RIPK1 (0.97) | RIPK1BMPR1BCDC7PIK3CDPLK4 | |
| SCHEMBL20477457 | 0.86 | RIPK1 (0.84) | RIPK1BMPR1BCDC7PIK3CDPLK4 | |
| SCHEMBL20549212 | 0.86 | RIPK1 (0.63) | RIPK1BMPR1BCDC7PIK3CDPLK4 | |
| SCHEMBL20549344 | 0.85 | RIPK1 (0.87) | RIPK1BMPR1BCDC7PIK3CDPLK4 | |
| SCHEMBL20477384 | 0.84 | RIPK1 (0.80) | RIPK1BMPR1BCDC7PIK3CDPLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3366684-B1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICALS CO (JP) | 2020-09-02 | — | — | EP | disclosed |
| EP-3366684-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2018-08-29 | — | — | EP | disclosed |