SCHEMBL2048165

SCHEMBL2048165

c1ccc([Si](O/N=C2/CCCC/C2=N\O[Si](c2ccccc2)(c2ccccc2)c2ccccc2)(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.33
LMNA P02545 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.32
TSHR P16473 1/20 0.31
GAA P10253 1/20 0.31
RAB9A P51151 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
CHRNB4 P30926 1/20 0.31
CHRNA3 P32297 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2048167 1.00 HPGD (0.33) HPGDLMNAL3MBTL1TSHRGAA
SCHEMBL9898743 0.88 GAA (0.38) GAARAB9ASMN1; SMN2
SCHEMBL9898744 0.88 GAA (0.38) GAARAB9ASMN1; SMN2
SCHEMBL214990 0.84 GAA (0.41) TSHRGAARAB9ASMN1; SMN2CHRNB4
SCHEMBL212164 0.82 GAA (0.40) L3MBTL1TSHRGAARAB9ASMN1; SMN2
SCHEMBL9898973 0.81 HTT (0.33) L3MBTL1GAARAB9ASMN1; SMN2
SCHEMBL9898976 0.81 HTT (0.33) L3MBTL1GAARAB9ASMN1; SMN2
SCHEMBL9899378 0.80 HTT (0.33) L3MBTL1GAARAB9ASMN1; SMN2
SCHEMBL9899379 0.80 HTT (0.33) L3MBTL1GAARAB9ASMN1; SMN2
SCHEMBL2044914 0.79 GAA (0.33) GAARAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2516475-B1 POLYMERS FUNCTIONALIZED WITH POLYOXIME COMPOUNDS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORP (JP) 2020-10-07 EP claimed
US-8338544-B2 Polymers functionalized with polyoxime compounds and methods for their manufacture BRIDGESTONE CORPORATION (JP) 2012-12-25 US claimed
US-20110152449-A1 POLYMERS FUNCTIONALIZED WITH POLYOXIME COMPOUNDS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-06-23 US claimed
EP-2516475-B1 POLYMERS FUNCTIONALIZED WITH POLYOXIME COMPOUNDS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORP (JP) 2020-10-07 EP disclosed
US-8338544-B2 Polymers functionalized with polyoxime compounds and methods for their manufacture BRIDGESTONE CORPORATION (JP) 2012-12-25 US disclosed
US-20110152449-A1 POLYMERS FUNCTIONALIZED WITH POLYOXIME COMPOUNDS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-06-23 US disclosed