Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.38 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 17/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20484351 | 0.87 | MAPK14 (0.42) | MAPK14 | |
| SCHEMBL20484315 | 0.86 | MAPKAPK2 (0.38) | MAPKAPK2MAPKAPK5MAPK14 | |
| SCHEMBL9111934 | 0.86 | MAPKAPK2 (0.39) | MAPKAPK2MAPKAPK5MAPK14 | |
| SCHEMBL9111824 | 0.86 | MAPKAPK2 (0.52) | MAPKAPK2MAPKAPK5MAPK14MAPK1 | |
| SCHEMBL9109602 | 0.85 | MAPKAPK5 (0.54) | MAPKAPK2MAPKAPK5MAPK14MAPK1 | |
| SCHEMBL20484362 | 0.83 | MAPKAPK5 (0.40) | MAPKAPK2MAPKAPK5MAPK14MAPK1 | |
| SCHEMBL9109373 | 0.80 | MAPKAPK2 (0.45) | MAPKAPK2MAPKAPK5MAPK14MAPK1 | |
| SCHEMBL9109550 | 0.79 | MAPK14 (0.37) | MAPKAPK2MAPKAPK5MAPK14MAPK1 | |
| SCHEMBL20484279 | 0.79 | MAPK14 (0.40) | MAPK14 | |
| SCHEMBL9110580 | 0.79 | MAPKAPK2 (0.45) | MAPKAPK2MAPKAPK5MAPK14MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2648516-B1 | SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | ACLARIS THERAPEUTICS INC (US) | 2018-09-05 | — | — | EP | claimed |