Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 18/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 17/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 16/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20484352 | 0.88 | MAPKAPK2 (0.37) | MAPKAPK5MAPK14MAPK1MAPKAPK2 | |
| SCHEMBL9112052 | 0.86 | MAPKAPK2 (0.52) | MAPKAPK5MAPK14MAPK1MAPKAPK2 | |
| SCHEMBL9112324 | 0.86 | MAPKAPK2 (0.41) | MAPKAPK5MAPK14MAPK1MAPKAPK2 | |
| SCHEMBL9110909 | 0.84 | MAPKAPK5 (0.53) | MAPKAPK5MAPK14MAPK1MAPKAPK2 | |
| SCHEMBL20484289 | 0.83 | MAPKAPK2 (0.38) | MAPKAPK5MAPK14MAPK1MAPKAPK2 | |
| SCHEMBL9110551 | 0.81 | MAPKAPK2 (0.57) | MAPKAPK5MAPK14MAPK1MAPKAPK2 | |
| SCHEMBL9110677 | 0.81 | MAPKAPK2 (0.46) | MAPKAPK5MAPK14MAPK1MAPKAPK2 | |
| SCHEMBL9108494 | 0.81 | MAPKAPK2 (0.45) | MAPKAPK5MAPK14MAPK1MAPKAPK2 | |
| SCHEMBL20484385 | 0.80 | JMJD6 (0.32) | MAPK14MAPKAPK2 | |
| SCHEMBL9111769 | 0.80 | MAPKAPK2 (0.36) | MAPKAPK5MAPK14MAPK1MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2648516-B1 | SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | ACLARIS THERAPEUTICS INC (US) | 2018-09-05 | — | — | EP | claimed |