SCHEMBL20486161

SCHEMBL20486161

[c]1cccc(-c2cnc3ccc(-c4cccs4)nn23)c1

nearest known ligand 0.73

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
FYN P06241 17/20 0.73
GRK5 P34947 1/20 0.57
CAMK2D Q13557 3/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18613886 0.84 FYN (1.00) FYNGRK5CAMK2D
SCHEMBL20485758 0.84 FYN (0.73) FYN
SCHEMBL18613329 0.83 FYN (1.00) FYNGRK5CAMK2D
SCHEMBL20486271 0.81 FYN (0.62) FYN
SCHEMBL16331632 0.80 FYN (1.00) FYN
SCHEMBL20485794 0.80 FYN (0.74) FYN
SCHEMBL20485751 0.80 FYN (0.67) FYN
SCHEMBL20485734 0.78 FYN (0.69) FYN
SCHEMBL20485664 0.78 FYN (0.65) FYN
SCHEMBL18613381 0.77 FYN (1.00) FYNGRK5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10688093-B2 Methods, compositions, and uses of novel Fyn kinase inhibitors Pathways Neuro Pharma, Inc. 2020-06-23 US disclosed
US-20180250297-A1 Methods, Compositions, and Uses of Novel FYN Kinase Inhibitors Pathways Neuro Pharma, Inc. 2018-09-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180250297-A1 Methods, Compositions, and Uses of Novel FYN Kinase Inhibitors FYN, LCK, PTK2B FYN 1/4885GRK5 34/4885CAMK2D 167/4885
US-10688093-B2 Methods, compositions, and uses of novel Fyn kinase inhibitors FYN, LCK, PTK2B FYN 1/4885GRK5 34/4885CAMK2D 167/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.