Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 7/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.58 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.58 |
| ▸ | RXRA | P19793 | 1/20 | 0.55 |
| ▸ | RXRB | P28702 | 1/20 | 0.55 |
| ▸ | RXRG | P48443 | 1/20 | 0.55 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20490227 | 0.91 | HDAC4 (0.70) | HDAC4HDAC7HDAC5HDAC8HDAC3 | |
| SCHEMBL2870552 | 0.90 | HDAC4 (0.72) | HDAC4HDAC7HDAC5HDAC8HDAC3 | |
| SCHEMBL20490427 | 0.87 | HDAC4 (0.61) | HDAC4HDAC7HDAC5HDAC8HDAC3 | |
| SCHEMBL20490367 | 0.87 | HDAC4 (0.60) | HDAC4HDAC7HDAC5HDAC8HDAC3 | |
| SCHEMBL27777137 | 0.87 | HDAC4 (0.78) | HDAC4HDAC7HDAC5HDAC8HDAC3 | |
| SCHEMBL20490331 | 0.85 | HDAC4 (0.54) | HDAC4HDAC7HDAC5HDAC8HDAC3 | |
| SCHEMBL2842461 | 0.85 | HDAC4 (0.81) | HDAC4HDAC7HDAC5HDAC8HDAC3 | |
| SCHEMBL20490466 | 0.84 | HDAC4 (0.60) | HDAC4HDAC7HDAC5HDAC8HDAC3 | |
| SCHEMBL4539938 | 0.84 | HDAC4 (0.66) | HDAC4HDAC7HDAC5HDAC8HDAC3 | |
| SCHEMBL20490608 | 0.84 | HDAC4 (0.63) | HDAC4HDAC7HDAC5HDAC8HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139850-B1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC (CA) | 2018-09-12 | — | — | EP | claimed |
| EP-2139850-B1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC (CA) | 2018-09-12 | — | — | EP | disclosed |