Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 7/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTR1E | P28566 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20490461 | 0.93 | HDAC4 (0.58) | HDAC4HDAC7HDAC5HDAC3HDAC8 | |
| SCHEMBL20490201 | 0.85 | HDAC4 (0.58) | HDAC4HDAC7HDAC5HDAC3HDAC8 | |
| SCHEMBL20490545 | 0.85 | HDAC4 (0.55) | HDAC4HDAC7HDAC5HDAC3HDAC8 | |
| SCHEMBL20490372 | 0.84 | ALDH1A1 (0.52) | HDAC4HDAC7HDAC5HDAC3HDAC8 | |
| SCHEMBL20490367 | 0.84 | HDAC4 (0.60) | HDAC4HDAC7HDAC5HDAC3HDAC8 | |
| SCHEMBL20490427 | 0.84 | HDAC4 (0.61) | HDAC4HDAC7HDAC5HDAC3HDAC8 | |
| SCHEMBL2870552 | 0.83 | HDAC4 (0.72) | HDAC4HDAC7HDAC5HDAC3HDAC8 | |
| SCHEMBL20490343 | 0.82 | HDAC4 (0.62) | HDAC4HDAC7HDAC5HDAC3HDAC8 | |
| SCHEMBL20490391 | 0.82 | HDAC4 (0.62) | HDAC4HDAC7HDAC5HDAC3HDAC8 | |
| SCHEMBL20490387 | 0.82 | HDAC4 (0.55) | HDAC4HDAC7HDAC5HDAC3HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139850-B1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC (CA) | 2018-09-12 | — | — | EP | claimed |
| EP-2139850-B1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC (CA) | 2018-09-12 | — | — | EP | disclosed |