Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.65 |
| ▸ | INSR | P06213 | 9/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20490705 | 0.96 | ALK (0.71) | ALKINSRKCNH2 | |
| SCHEMBL20567274 | 0.89 | ALK (0.66) | ALKINSRKCNH2 | |
| SCHEMBL28427764 | 0.87 | ALK (0.67) | ALKINSRKCNH2 | |
| SCHEMBL20567914 | 0.84 | ALK (0.73) | ALKINSRKCNH2 | |
| SCHEMBL20490720 | 0.84 | ALK (0.81) | ALKINSRKCNH2 | |
| SCHEMBL25566496 | 0.81 | ALK (0.90) | ALKINSRKCNH2 | |
| SCHEMBL25566500 | 0.80 | ALK (0.81) | ALKINSRKCNH2 | |
| SCHEMBL25569248 | 0.79 | ALK (0.77) | ALKINSRKCNH2 | |
| SCHEMBL25566486 | 0.79 | ALK (0.79) | ALKINSRKCNH2 | |
| SCHEMBL25566006 | 0.79 | ALK (0.90) | ALKINSRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3372594-B1 | PYRIMIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER | HUMANWELL HEALTHCARE GROUP CO LTD (CN) | 2021-07-21 | — | — | EP | disclosed |
| EP-3372594-A1 | PYRIMIDINE DERIVATIVE AND USE THEREOF | Humanwell Healthcare (Group) Co., Ltd. (CN) | 2018-09-12 | — | — | EP | disclosed |