Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.66 |
| ▸ | INSR | P06213 | 8/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20567914 | 0.95 | ALK (0.73) | ALKINSRKCNH2 | |
| SCHEMBL20490716 | 0.89 | ALK (0.65) | ALKINSRKCNH2 | |
| SCHEMBL20490720 | 0.87 | ALK (0.81) | ALKINSRKCNH2 | |
| SCHEMBL28427764 | 0.86 | ALK (0.67) | ALKINSRKCNH2 | |
| SCHEMBL20490705 | 0.84 | ALK (0.71) | ALKINSRKCNH2 | |
| SCHEMBL25566496 | 0.83 | ALK (0.90) | ALKINSRKCNH2 | |
| SCHEMBL25566500 | 0.81 | ALK (0.81) | ALKINSRKCNH2 | |
| SCHEMBL25566486 | 0.80 | ALK (0.79) | ALKINSRKCNH2 | |
| SCHEMBL25566006 | 0.80 | ALK (0.90) | ALKINSRKCNH2 | |
| SCHEMBL17303709 | 0.80 | ALK (0.78) | ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10695347-B2 | Pyrimidine derivative and use thereof | HUBEI BIO-PHARMACEUTICAL INDUSTRIAL TECHNOLOGICAL INSTITUTE, INC. (CN) | 2020-06-30 | — | — | US | disclosed |
| US-20180338973-A1 | PYRIMIDINE DERIVATIVE AND USE THEREOF | HUBEI BIO-PHARMACEUTICAL INDUSTRIAL TECHNOLOGICAL INSTITUTE, INC. (CN) | 2018-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180338973-A1 | PYRIMIDINE DERIVATIVE AND USE THEREOF | ALK, DPYD, TYMP | ALK 1/4885INSR 992/4885KCNH2 1598/4885 |
| US-10695347-B2 | Pyrimidine derivative and use thereof | ALK, DPYD, TYMP | ALK 1/4885INSR 992/4885KCNH2 1598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.