Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.36 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.36 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29542537 | 0.82 | BCHE (0.42) | ALDH1A1POLBPGRHTTTSHR | |
| SCHEMBL28357629 | 0.77 | HTT (0.46) | ALDH1A1PGRHTTHSD17B10GAA | |
| SCHEMBL31220071 | 0.73 | ALDH1A1 (0.41) | ALDH1A1HTTHSD17B10MAPTKMT2A | |
| SCHEMBL19211064 | 0.69 | TP53 (0.34) | ALDH1A1HTTKDM4EPKM | |
| SCHEMBL25180710 | 0.68 | HSD17B10 (0.45) | ALDH1A1PGRHTTTSHRHSD17B10 | |
| SCHEMBL2126710 | 0.68 | MAPT (0.37) | ALDH1A1HPGDMAPTKMT2AKDM4E | |
| SCHEMBL25310976 | 0.67 | EGLN1 (0.48) | ALDH1A1HTTHSD17B10GAAKDM4E | |
| SCHEMBL20495542 | 0.67 | PDK2 (0.42) | ALDH1A1HSD17B10HPGDMAPTKMT2A | |
| SCHEMBL29092419 | 0.65 | HSD17B10 (0.39) | ALDH1A1POLBHTTHSD17B10MAPT | |
| SCHEMBL13233714 | 0.65 | HSD17B10 (0.56) | ALDH1A1POLBPGRHTTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210284650-A1 | SPIROOXINDOLE COMPOUNDS AS GSK3B INHIBITORS AND PROCESS FOR PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2021-09-16 | — | — | US | disclosed |
| WO-2018163216-A1 | SPIROOXINDOLE COMPOUNDS AS GSK3Β INHIBITORS AND PROCESS FOR PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2018-09-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210284650-A1 | SPIROOXINDOLE COMPOUNDS AS GSK3B INHIBITORS AND PROCESS FOR PREPARATION THEREOF | GSK3B, GSK3A, GSKIP | ALDH1A1 887/4885POLB 585/4885PGR 2519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.