Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21807152 | 0.88 | DPP4 (0.37) | RIPK1KDM4EALDH1A1 | |
| SCHEMBL4893081 | 0.86 | GAA (0.36) | ALDH1A1 | |
| SCHEMBL34472707 | 0.81 | TP53 (0.32) | TP53 | |
| SCHEMBL3660031 | 0.75 | CA1 (0.33) | — | |
| SCHEMBL6097416 | 0.72 | — | — | |
| SCHEMBL8509354 | 0.69 | DPP4 (0.36) | — | |
| SCHEMBL21063648 | 0.69 | TP53 (0.33) | KDM4EALDH1A1TP53 | |
| SCHEMBL26927164 | 0.69 | NPC1 (0.34) | KDM4EALDH1A1TP53 | |
| SCHEMBL28059103 | 0.68 | CA12 (0.37) | ALDH1A1 | |
| SCHEMBL27368424 | 0.68 | POLB (0.35) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3609888-A1 | FARNESOID X RECEPTOR AGONISTS AND USES THEREOF | Metacrine, Inc. (US) | 2020-02-19 | — | — | EP | claimed |
| WO-2018170182-A1 | FARNESOID X RECEPTOR AGONISTS AND USES THEREOF | METACRINE, INC. (US) | 2018-09-20 | — | — | WO | claimed |