Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | PREP | P48147 | 1/20 | 0.37 |
| ▸ | FAP | Q12884 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 9/20 | 0.34 |
| ▸ | ACE | P12821 | 4/20 | 0.33 |
| ▸ | REN | P00797 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PEPD | P12955 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4893081 | 0.94 | GAA (0.36) | DPP4PREPFAPPOLBL3MBTL1 | |
| SCHEMBL20501449 | 0.88 | RIPK1 (0.33) | RIPK1KDM4EALDH1A1 | |
| SCHEMBL8509354 | 0.82 | DPP4 (0.36) | DPP4PREPFAPPOLBL3MBTL1 | |
| SCHEMBL27368424 | 0.82 | POLB (0.35) | DPP4PREPFAPRIPK1POLB | |
| SCHEMBL4623155 | 0.80 | POLB (0.34) | DPP4PREPFAPRIPK1POLB | |
| SCHEMBL2707073 | 0.80 | CA2 (0.39) | DPP4PREPFAPRIPK1POLB | |
| SCHEMBL4623157 | 0.80 | POLB (0.34) | DPP4PREPFAPRIPK1POLB | |
| SCHEMBL28059103 | 0.77 | CA12 (0.37) | DPP4PREPFAPPOLBALDH1A1 | |
| SCHEMBL26984528 | 0.76 | RAB9A (0.38) | L3MBTL1KDM4EACERENLMNA | |
| SCHEMBL27094468 | 0.74 | GAA (0.33) | DPP4PREPFAPL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3853233-A1 | TRI-SUBSTITUTED HETEROARYL DERIVATIVES AS SRC HOMOLOGY-2 PHOSPHATASE INHIBITORS | Nikang Therapeutics, Inc. (US) | 2021-07-28 | — | — | EP | disclosed |
| WO-2020061101-A1 | TRI-SUBSTITUTED HETEROARYL DERIVATIVES AS SRC HOMOLOGY-2 PHOSPHATASE INHIBITORS | NIKANG THERAPEUTICS, INC. (US) | 2020-03-26 | — | — | WO | disclosed |