Known targets — ChEMBL curated mechanism
ATP1A1ATP1A2ATP1A3ATP1A4ATP1B1ATP1B2ATP1B3FXYD2
The experimentally established mechanism targets of Digoxin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP1A1 known ✓ | P05023 | 15/20 | 1.00 |
| ▸ | ATP1B1 known ✓ | P05026 | 15/20 | 1.00 |
| ▸ | ATP1B2 known ✓ | P14415 | 15/20 | 1.00 |
| ▸ | ATP1A2 known ✓ | P50993 | 15/20 | 1.00 |
| ▸ | ATP1B3 known ✓ | P54709 | 15/20 | 1.00 |
| ▸ | ATP1A3 known ✓ | P13637 | 3/20 | 1.00 |
| ▸ | FXYD2 known ✓ | P54710 | 3/20 | 1.00 |
| ▸ | ATP1A4 known ✓ | Q13733 | 3/20 | 1.00 |
| ▸ | TP53 | P04637 | 4/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | NPC1 | O15118 | 2/20 | 1.00 |
| ▸ | STAT3 | P40763 | 2/20 | 1.00 |
| ▸ | RAB9A | P51151 | 2/20 | 1.00 |
| ▸ | GLA | P06280 | 1/20 | 1.00 |
| ▸ | RECQL | P46063 | 1/20 | 1.00 |
| ▸ | RORC | P51449 | 1/20 | 1.00 |
| ▸ | PAX8 | Q06710 | 1/20 | 1.00 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 1.00 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Digoxin SCHEMBL16341971 | 1.00 | ATP1A1 (1.00) | ATP1A1ATP1B1ATP1B2ATP1A2ATP1B3 | |
| Digoxin SCHEMBL15959376 | 1.00 | ATP1A1 (1.00) | ATP1A1ATP1B1ATP1B2ATP1A2ATP1B3 | |
| Digoxin SCHEMBL13496260 | 1.00 | ATP1A1 (1.00) | ATP1A1ATP1B1ATP1B2ATP1A2ATP1B3 | |
| Digoxin SCHEMBL13337586 | 1.00 | ATP1A1 (1.00) | ATP1A1ATP1B1ATP1B2ATP1A2ATP1B3 | |
| Digoxin SCHEMBL13354340 | 1.00 | ATP1A1 (1.00) | ATP1A1ATP1B1ATP1B2ATP1A2ATP1B3 | |
| Digoxin SCHEMBL12841137 | 1.00 | ATP1A1 (1.00) | ATP1A1ATP1B1ATP1B2ATP1A2ATP1B3 | |
| Digoxin SCHEMBL16144399 | 1.00 | ATP1A1 (1.00) | ATP1A1ATP1B1ATP1B2ATP1A2ATP1B3 | |
| Digoxin SCHEMBL8200838 | 1.00 | ATP1A1 (1.00) | ATP1A1ATP1B1ATP1B2ATP1A2ATP1B3 | |
| Digoxin SCHEMBL22904197 | 1.00 | ATP1A1 (1.00) | ATP1A1ATP1B1ATP1B2ATP1A2ATP1B3 | |
| Digoxin SCHEMBL13199062 | 1.00 | ATP1A1 (1.00) | ATP1A1ATP1B1ATP1B2ATP1A2ATP1B3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 73841 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116200391-B | Nucleic acid aptamer combined with novel coronavirus SARS-CoV-2 Spike protein and application thereof | SICHUAN UNIVERSITY (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-122081310-A | Screening method of high-specificity nucleic acid aptamer and specific lactobacillus helveticus aptamer | — | 2026-05-26 | — | — | CN | claimed |
| CN-122081511-A | Fluorescence in situ hybridization method for polygenic co-localization of shellfish blood lymphocytes | — | 2026-05-26 | — | — | CN | claimed |
| WO-2026103722-A1 | COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF COAGULATION FACTOR XI (FXI) | SHANGHAI ARGO BIOPHARMACEUTICAL CO., LTD. (CN) | 2026-05-21 | — | — | WO | claimed |
| US-20260137707-A1 | METHODS OF MODULATING ATXN2 EXPRESSION | UNIV OF UTAH RESEARCH FOUNDATION (US) | 2026-05-21 | — | — | US | claimed |
| WO-2026102542-A1 | ATPASE INHIBITORS FOR TREATMENT OF NEUROLOGICAL AND NON-NEUROLOGICAL DISORDERS | HAPLO THERAPEUTICS INC. (CA) | 2026-05-21 | — | — | WO | claimed |
| CN-122031677-A | Leptin receptor agonist antibodies for the treatment of metabolic dysfunction or hypoleptinemia | 瑞泽恩制药公司 | 2026-05-15 | — | — | CN | claimed |
| CN-122038586-A | Bicolor fluorescence in situ hybridization probe for identifying Eccyp a1 and Vasa gene expression and application thereof | 中国水产科学研究院黄海水产研究所 | 2026-05-15 | — | — | CN | claimed |
| CN-122029176-A | Containing a plurality of oligonucleotides modified oligonucleotides | 阿达尔克斯制药有限公司 | 2026-05-12 | — | — | CN | claimed |
| CN-121342988-B | Antibody CM0735 and uses thereof | 北京大学人民医院 | 2026-05-12 | — | — | CN | claimed |
| US-4021535-A | Reagents used in the radioimmunoassay of digoxin | BECKMAN INSTRUMENTS, INC. (US) | 1977-05-03 | — | — | US | claimed |
| US-4017597-A | STORAGE STABILITY, MEDICAL DIAGNOSIS | MONSANTO COMPANY (US) | 1977-04-12 | — | — | US | claimed |
| US-4002718-A | Gelatin-encapsulated digoxin solutions and method of preparing the same | ARNAR-STONE LABORATORIES, INC. (US) | 1977-01-11 | — | — | US | claimed |
| US-3997525-A | Tetra-125 iodo-di-tyramine of digitalis derivative and process for making the same | BIO-TEC, INC. (US) | 1976-12-14 | — | — | US | claimed |
| US-3995019-A | FOR RADIOIMMUNOASSAY CONSISTING OF A SPECIFIC ANTIBODY RADIOLABELED, ANTIGEN, POLYETHYLENE GLYCOL, AND GAMMA GLOBULIN | BAXTER TRAVENOL LABORATORIES, INC. (US) | 1976-11-30 | — | — | US | claimed |
| US-3981982-A | Radioimmunoassay for determining the digoxin content of a sample | ABBOTT LABORATORIES (US) | 1976-09-21 | — | — | US | claimed |
| US-3981862-A | Preparation of C22-alkyl derivative of digoxin | BOEHRINGER MANNHEIM G.M.B.H. (DT) | 1976-09-21 | — | — | US | claimed |
| US-3980764-A | Polymeric competitive protein binding adsorbents for radioassey | CURTIS NUCLEAR CORPORATION (US) | 1976-09-14 | — | — | US | claimed |
| US-3975511-A | Solid phase radioimmunoassay | CORNING GLASS WORKS (US) | 1976-08-17 | — | — | US | claimed |
| US-3933997-A | RADIOACTIVITY, SILANE COUPLING AGENT | CORNING GLASS WORKS (US) | 1976-01-20 | — | — | US | claimed |