Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.55 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 14/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 14/20 | 0.33 |
| ▸ | ERBB3 | P21860 | 14/20 | 0.33 |
| ▸ | ERBB4 | Q15303 | 14/20 | 0.33 |
| ▸ | EIF4E | P06730 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2739652 | 0.85 | DYRK1A (0.53) | DYRK1AIRAK4EGFRERBB2ERBB3 | |
| SCHEMBL13186164 | 0.71 | DYRK1A (0.59) | DYRK1AIRAK4EGFRERBB2ERBB3 | |
| SCHEMBL8223 | 0.71 | DYRK1A (1.00) | DYRK1AIRAK4EGFRERBB2ERBB3 | |
| SCHEMBL2078428 | 0.67 | DYRK1A (0.59) | DYRK1AIRAK4EGFRERBB2ERBB3 | |
| SCHEMBL397656 | 0.67 | DYRK1A (0.59) | DYRK1AIRAK4EGFREIF4EMKNK1 | |
| SCHEMBL23158613 | 0.67 | DYRK1A (0.64) | DYRK1AIRAK4EGFRERBB2ERBB3 | |
| SCHEMBL29702869 | 0.67 | DYRK1A (0.59) | DYRK1AIRAK4EGFREIF4EMKNK1 | |
| SCHEMBL1056424 | 0.67 | DYRK1A (0.59) | DYRK1AIRAK4EGFRERBB2ERBB3 | |
| SCHEMBL3386908 | 0.67 | DYRK1A (0.59) | DYRK1AIRAK4EGFRERBB2ERBB3 | |
| SCHEMBL20576054 | 0.67 | DYRK1A (0.53) | DYRK1AIRAK4EGFRERBB2ERBB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3377494-A1 | PYRROPYRIMIDINE COMPOUNDS AS MNKS INHIBITORS | LifeArc (GB) | 2018-09-26 | — | — | EP | disclosed |