Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 17/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20557242 | 0.90 | TYK2 (0.44) | TYK2PDE4DPDE4B | |
| SCHEMBL20506393 | 0.88 | TYK2 (0.43) | TYK2PDE4DCCNE1CDK2 | |
| SCHEMBL22421813 | 0.82 | TYK2 (0.45) | TYK2PDE4DPDE4B | |
| SCHEMBL20504586 | 0.82 | TYK2 (0.46) | TYK2PDE4DPDE4B | |
| SCHEMBL20505900 | 0.79 | TYK2 (0.43) | TYK2PDE4DALDH1A1PDE4B | |
| SCHEMBL20049793 | 0.77 | TYK2 (0.39) | TYK2PDE4D | |
| SCHEMBL21175119 | 0.76 | TYK2 (0.41) | TYK2PDE4D | |
| SCHEMBL21175121 | 0.76 | TYK2 (0.41) | TYK2PDE4D | |
| SCHEMBL20049687 | 0.75 | TYK2 (0.43) | TYK2PDE4D | |
| SCHEMBL20049754 | 0.74 | TYK2 (0.44) | TYK2PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3377496-A1 | IMIDAZOPYRIDAZINE COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES | Bristol-Myers Squibb Company (US) | 2018-09-26 | — | — | EP | disclosed |