Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 9/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | TSPO | P30536 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20557551 | 0.87 | TYK2 (0.45) | TYK2PDE4DMAPTADORA3ADORA2A | |
| SCHEMBL20505904 | 0.86 | TYK2 (0.42) | TYK2PDE4DMAPTADORA3ADORA2A | |
| SCHEMBL20506392 | 0.79 | TYK2 (0.42) | TYK2PDE4DPDE4BALDH1A1 | |
| SCHEMBL24263379 | 0.78 | TYK2 (0.46) | TYK2PDE4DMAPTADORA3ADORA2A | |
| SCHEMBL20557221 | 0.78 | MAPT (0.39) | MAPTADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL20504574 | 0.75 | IDO1 (0.37) | TYK2PDE4DMAPTADORA3ADORA2A | |
| SCHEMBL16794637 | 0.75 | TYK2 (0.45) | TYK2PDE4DMAPTADORA3ADORA2A | |
| SCHEMBL24263290 | 0.73 | GAA (0.37) | TYK2PDE4DMAPTADORA3ADORA2A | |
| SCHEMBL30392961 | 0.73 | FAAH (0.37) | TYK2PDE4DMAPTADORA3ADORA2A | |
| SCHEMBL26100287 | 0.73 | FAAH (0.37) | TYK2PDE4DMAPTADORA3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3377496-A1 | IMIDAZOPYRIDAZINE COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES | Bristol-Myers Squibb Company (US) | 2018-09-26 | — | — | EP | disclosed |