Etorphine

Etorphine

SCHEMBL20507

CCC[C@@](C)(O)[C@H]1C[C@@]23C=C[C@]1(OC)[C@@H]1Oc4c(O)ccc5c4[C@@]12CCN(C)[C@@H]3C5

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
OPRK1 P41145 10/20 1.00
OPRM1 P35372 9/20 1.00
OPRD1 P41143 9/20 1.00
OPRL1 P41146 1/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Etorphine SCHEMBL25681403 1.00 OPRK1 (1.00) OPRK1OPRM1OPRD1OPRL1
Etorphine SCHEMBL12125405 1.00 OPRK1 (1.00) OPRK1OPRM1OPRD1OPRL1
Etorphine SCHEMBL15013782 1.00 OPRK1 (1.00) OPRK1OPRM1OPRD1OPRL1
Etorphine SCHEMBL12230551 1.00 OPRK1 (1.00) OPRK1OPRM1OPRD1OPRL1
Etorphine SCHEMBL140251 1.00 OPRK1 (1.00) OPRK1OPRM1OPRD1OPRL1
Etorphine SCHEMBL19565627 1.00 OPRK1 (1.00) OPRK1OPRM1OPRD1OPRL1
Etorphine SCHEMBL19564457 1.00 OPRK1 (1.00) OPRK1OPRM1OPRD1OPRL1
Etorphine SCHEMBL10031275 1.00 OPRK1 (1.00) OPRK1OPRM1OPRD1OPRL1
Etorphine SCHEMBL14516216 1.00 OPRK1 (1.00) OPRK1OPRM1OPRD1OPRL1
Etorphine SCHEMBL29381660 1.00 OPRK1 (1.00) OPRK1OPRM1OPRD1OPRL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 20309 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4255391-B1 LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION METRIOPHARM AG (CH) 2026-05-06 EP claimed
EP-4724049-A1 MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF Catalent Ontario Limited (CA) 2026-04-15 EP claimed
US-12564597-B2 Ibogaine analogs as therapeutics for neurological and psychiatric disorders THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE OF NEW YORK (US) 2026-03-03 US claimed
US-12472202-B2 Compositions and their use in the treatment of endometriosis and pain RR Medsciences PTY, LTD (AU) 2025-11-18 US claimed
US-12440489-B2 Organic compounds INTRA-CELLULAR THERAPIES, INC. (US) 2025-10-14 US claimed
US-20250283129-A1 PROCESS SUN PHARMACEUTICAL INDUSTRIES AUSTRALIA PTY LIMITED (AU) 2025-09-11 US claimed
US-12383743-B2 Treatment of addiction and dependency TACA JR ARTURO C (US) 2025-08-12 US claimed
US-20250228771-A1 ALKALINE INTRAORAL PRODUCTS EMPLICURE AB (publ) (SE) 2025-07-17 US claimed
EP-4565202-A1 ALKALINE INTRAORAL PRODUCTS EMPLICURE AB (publ) (SE) 2025-06-11 EP claimed
WO-2025111482-A1 COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS BEXSON BIOMEDICAL, INC. (US) 2025-05-30 WO claimed
EP-0170090-B1 SUBSTITUTED BENZOATE ESTER PRODRUG DERIVATIVES OF 3-HYDROXYMORPHINANS, INTERMEDIATES THERETO, AND PROCESSES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1989-09-27 EP claimed
US-4829056-A MONOSACCHARIDES, DISACCHARIDES, XANTHAN GUM, LOCUST BEAN GUM RECKITT & COLMAN PRODUCTS LIMITED (GB) 1989-05-09 US claimed
EP-0250796-A2 Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1988-01-07 EP claimed
EP-0245952-A2 Buccal tablet comprising etorphine or a salt thereof RECKITT AND COLMAN PRODUCTS LIMITED (GB) 1987-11-19 EP claimed
EP-0243797-A2 Method for amplifying enzyme activity, enzyme conjugates suitable therefor and their preparation NORTHEASTERN UNIVERSITY (US) 1987-11-04 EP claimed
US-4673679-A ESTERS, CARBONATES, CARBAMATES, OR SULFONATES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1987-06-16 US claimed
US-4668685-A Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists E.I. DU PONT DE NEMOURS AND COMPANY (US) 1987-05-26 US claimed
EP-0170090-A1 Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, intermediates thereto, and processes E.I. DU PONT DE NEMOURS AND COMPANY (US) 1986-02-05 EP claimed
US-4473640-A OF DRUG-GLUCURONIC ACID COMPLEXES COMBIE JOAN D 1984-09-25 US claimed
US-4126684-A 4-AMINO-3-P-HALOPHENYLBUTYRIC ACIDS AND THEIR DERIVATIVES USED IN THE CONTROL OF NARCOTIC ABUSE CIBA-GEIGY CORPORATION (US) 1978-11-21 US claimed