Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 9/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | IGF1R | P08069 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | FLT4 | P35916 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.31 |
| ▸ | TEK | Q02763 | 1/20 | 0.31 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20508868 | 0.83 | DYRK1A (0.45) | DGAT1DYRK1APIM1DYRK2DYRK1B | |
| SCHEMBL20508770 | 0.80 | DYRK1A (0.38) | DGAT1DYRK1APIM1DYRK2DYRK1B | |
| SCHEMBL16177606 | 0.77 | LRRK2 (0.42) | DGAT1 | |
| SCHEMBL20449023 | 0.76 | MEN1 (0.38) | DGAT1DYRK1APIM1DYRK2DYRK1B | |
| SCHEMBL20508805 | 0.76 | DGAT1 (0.35) | DGAT1KLKB1 | |
| SCHEMBL20448951 | 0.75 | DYRK1A (0.45) | DGAT1DYRK1APIM1DYRK2DYRK1B | |
| SCHEMBL20508794 | 0.73 | DGAT1 (0.41) | DGAT1DYRK1A | |
| SCHEMBL20508783 | 0.73 | DYRK1A (0.56) | DYRK1APIM1DYRK2DYRK1B | |
| SCHEMBL12069755 | 0.72 | DGAT1 (0.41) | DGAT1PDE10AKLKB1MAPT | |
| SCHEMBL20162876 | 0.72 | LCK (0.39) | DGAT1SRCKDRTEKMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180273538-A1 | PYRROLO[2,3-d]PYRIMIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2018-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180273538-A1 | PYRROLO[2,3-d]PYRIMIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DPYD, TYMS, TYMP | DGAT1 3658/4885DYRK1A 1951/4885PIM1 3402/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.