Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIKFYVE | Q9Y2I7 | 11/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | FES | P07332 | 1/20 | 0.49 |
| ▸ | FER | P16591 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | FRK | P42685 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31089726 | 1.00 | PIKFYVE (0.76) | PIKFYVEKDM4EMAPTLMNAHPGD | |
| SCHEMBL20511324 | 1.00 | PIKFYVE (0.76) | PIKFYVEKDM4EMAPTLMNAHPGD | |
| SCHEMBL20511333 | 0.91 | PIKFYVE (0.65) | PIKFYVEKDM4EMAPTLMNAHPGD | |
| SCHEMBL20511365 | 0.89 | PIKFYVE (0.61) | PIKFYVEKDM4EMAPTLMNAHPGD | |
| SCHEMBL20511300 | 0.89 | PIKFYVE (0.61) | PIKFYVEKDM4EMAPTLMNAHPGD | |
| SCHEMBL31089708 | 0.89 | PIKFYVE (0.61) | PIKFYVEKDM4EMAPTLMNAHPGD | |
| SCHEMBL20511360 | 0.89 | PIKFYVE (0.61) | PIKFYVEKDM4EMAPTLMNAHPGD | |
| SCHEMBL20511305 | 0.89 | PIKFYVE (0.61) | PIKFYVEKDM4EMAPTLMNAHPGD | |
| SCHEMBL31089693 | 0.89 | PIKFYVE (0.61) | PIKFYVEKDM4EMAPTLMNAHPGD | |
| SCHEMBL20511320 | 0.89 | PIKFYVE (0.60) | PIKFYVEKDM4EMAPTLMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240294536-A1 | FUSED TRIAZOLO-PYRIMIDINE COMPOUNDS HAVING USEFUL PHARMACEUTICAL APPLICATION | PIKSCI INC. (CA) | 2024-09-05 | — | — | US | disclosed |
| US-11987583-B2 | Fused triazolo-pyrimidine compounds having useful pharmaceutical application | PIKSCI INC. (CA) | 2024-05-21 | — | — | US | disclosed |
| US-20240016810-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT AND PREVENTION OF NEUROLOGICAL DISORDERS | YUMANITY THERAPEUTICS, INC. | 2024-01-18 | — | — | US | disclosed |
| WO-2021252895-A2 | COMPOSITIONS AND METHODS FOR THE TREATMENT AND PREVENTION OF NEUROLOGICAL DISORDERS | YUMANITY THERAPEUTICS, INC. (US) | 2021-12-16 | — | — | WO | disclosed |
| US-20210323969-A1 | FUSED TRIAZOLO-PYRIMIDINE COMPOUNDS HAVING USEFUL PHARMACEUTICAL APPLICATION | PIKSCI INC. (CA) | 2021-10-21 | — | — | US | disclosed |
| US-20210323969-A1 | FUSED TRIAZOLO-PYRIMIDINE COMPOUNDS HAVING USEFUL PHARMACEUTICAL APPLICATION | PIKSCI INC. (CA) | 2021-10-21 | — | — | US | disclosed |
| US-11066410-B2 | Fused triazolo-pyrimidine compounds having useful pharmaceutical application | 3100 CENTRAL EXPRESSWAY LLC (US) | 2021-07-20 | — | — | US | disclosed |
| US-11066410-B2 | Fused triazolo-pyrimidine compounds having useful pharmaceutical application | 3100 CENTRAL EXPRESSWAY LLC (US) | 2021-07-20 | — | — | US | disclosed |
| US-20200079780-A1 | FUSED TRIAZOLO-PYRIMIDINE COMPOUNDS HAVING USEFUL PHARMACEUTICAL APPLICATION | NANOSYN, INC. | 2020-03-12 | — | — | US | disclosed |
| EP-3600328-A1 | FUSED TRIAZOLO-PYRIMIDINE COMPOUNDS HAVING USEFUL PHARMACEUTICAL APPLICATION | Nanosyn, Inc. (US) | 2020-02-05 | — | — | EP | disclosed |
| WO-2018175906-A1 | FUSED TRIAZOLO-PYRIMIDINE COMPOUNDS HAVING USEFUL PHARMACEUTICAL APPLICATION | NANOSYN, INC. (US) | 2018-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240016810-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT AND PREVENTION OF NEUROLOGICAL DISORDERS | TARDBP, PIKFYVE, FUS | PIKFYVE 2/4885KDM4E 788/4885MAPT 33/4885 |
| US-11987583-B2 | Fused triazolo-pyrimidine compounds having useful pharmaceutical application | PIKFYVE, PIP4K2B, PIP4K2A | PIKFYVE 1/4885KDM4E 1042/4885MAPT 2023/4885 |
| US-20210323969-A1 | FUSED TRIAZOLO-PYRIMIDINE COMPOUNDS HAVING USEFUL PHARMACEUTICAL APPLICATION | PIKFYVE, PIP4K2B, PIP4K2A | PIKFYVE 1/4885KDM4E 1042/4885MAPT 2023/4885 |
| US-11066410-B2 | Fused triazolo-pyrimidine compounds having useful pharmaceutical application | PIKFYVE, PIP4K2B, PIP4K2A | PIKFYVE 1/4885KDM4E 1042/4885MAPT 2023/4885 |
| US-20200079780-A1 | FUSED TRIAZOLO-PYRIMIDINE COMPOUNDS HAVING USEFUL PHARMACEUTICAL APPLICATION | PIKFYVE, PIP4K2B, PIP4K2A | PIKFYVE 1/4885KDM4E 1042/4885MAPT 2023/4885 |
| US-20240294536-A1 | FUSED TRIAZOLO-PYRIMIDINE COMPOUNDS HAVING USEFUL PHARMACEUTICAL APPLICATION | PIKFYVE, PIP4K2B, PIK3CA | PIKFYVE 1/4885KDM4E 536/4885MAPT 3840/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.