Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.48 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20514025 | 0.82 | GAA (0.58) | SMN1; SMN2HPGDKMT2AGAASIRT5 | |
| SCHEMBL20166840 | 0.81 | SMN1; SMN2 (0.64) | SMN1; SMN2HPGDKMT2AMTNR1AMTNR1B | |
| SCHEMBL20166584 | 0.78 | SMN1; SMN2 (0.60) | SMN1; SMN2HPGDKMT2AMTNR1AMTNR1B | |
| SCHEMBL20984589 | 0.77 | CA12 (0.48) | SMN1; SMN2HPGDKMT2AGAAALDH1A1 | |
| SCHEMBL14503304 | 0.73 | SMN1; SMN2 (1.00) | SMN1; SMN2HPGDKMT2AGAAALDH1A1 | |
| SCHEMBL20268099 | 0.70 | HPGD (0.66) | SMN1; SMN2P2RX7HPGDKMT2AGAA | |
| SCHEMBL20984476 | 0.70 | GAA (0.43) | SMN1; SMN2P2RX7KMT2AGAAALDH1A1 | |
| SCHEMBL7431354 | 0.69 | HPGD (0.69) | SMN1; SMN2P2RX7HPGDGAAALDH1A1 | |
| SCHEMBL20515262 | 0.69 | KMT2A (0.50) | SMN1; SMN2HPGDKMT2AGAAALDH1A1 | |
| SCHEMBL5923744 | 0.69 | P2RX7 (0.97) | SMN1; SMN2P2RX7HPGDGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3380970-A1 | NOVEL AZOLE DERIVATIVES AS APELIN RECEPTOR AGONIST | Sanford Burnham Prebys Medical Discovery Institute (US) | 2018-10-03 | — | — | EP | disclosed |