Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ACACA | Q13085 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17938379 | 0.78 | MTNR1A (0.37) | TLR8KDRPDGFRBPARP1TP53 | |
| SCHEMBL28878229 | 0.74 | TLR8 (0.46) | TLR8TP53MEN1KMT2AKDM4E | |
| Ammonia Solution, Strong SCHEMBL4555054 | 0.74 | TLR8 (0.49) | TLR8TP53MEN1KMT2AGABRA1 | |
| Formamide SCHEMBL5260604 | 0.72 | TLR8 (0.47) | TLR8PARP1TP53MEN1KMT2A | |
| SCHEMBL28794630 | 0.68 | TLR8 (0.39) | TLR8PARP1KDM4E | |
| SCHEMBL21555488 | 0.68 | TLR8 (0.64) | TLR8CYP1A2 | |
| SCHEMBL15112010 | 0.67 | KMT2A (0.40) | TLR8KDRPDGFRBPARP1MEN1 | |
| SCHEMBL29145135 | 0.67 | ASAH1 (0.46) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL16510477 | 0.66 | MEN1 (0.44) | TLR8TP53MEN1KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL28791312 | 0.66 | KMT2A (0.39) | TLR8KDRPDGFRBPARP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |