Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 20/20 | 0.82 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.82 |
| ▸ | CHEK2 | O96017 | 7/20 | 0.82 |
| ▸ | CDK1 | P06493 | 2/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20516616 | 1.00 | CHEK1 (0.82) | CHEK1KCNH2CHEK2CDK1 | |
| SCHEMBL30637885 | 1.00 | CHEK1 (0.82) | CHEK1KCNH2CHEK2CDK1 | |
| SCHEMBL12985426 | 0.91 | CHEK1 (0.82) | CHEK1KCNH2CHEK2CDK1 | |
| SCHEMBL12984696 | 0.91 | CHEK1 (0.82) | CHEK1KCNH2CHEK2CDK1 | |
| SCHEMBL13029116 | 0.91 | CHEK1 (0.82) | CHEK1KCNH2CHEK2CDK1 | |
| SCHEMBL1396946 | 0.90 | CHEK1 (1.00) | CHEK1KCNH2CHEK2CDK1 | |
| SCHEMBL13028631 | 0.90 | CHEK1 (0.80) | CHEK1KCNH2CHEK2CDK1 | |
| SCHEMBL1396948 | 0.90 | CHEK1 (1.00) | CHEK1KCNH2CHEK2CDK1 | |
| SCHEMBL13029735 | 0.90 | CHEK1 (0.80) | CHEK1KCNH2CHEK2CDK1 | |
| SCHEMBL30503387 | 0.90 | CHEK1 (1.00) | CHEK1KCNH2CHEK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117024411-A | Isoquinoline as HPK1 inhibitor | 豪夫迈·罗氏有限公司 | 2023-11-10 | — | — | CN | claimed |
| CN-110709392-A | Isoquinoline as HPK1 inhibitors | 豪夫迈·罗氏有限公司 | 2020-01-17 | — | — | CN | claimed |
| US-20180282282-A1 | ISOQUINOLINES AS INHIBITORS OF HPK1 | GENENTECH, INC. (US) | 2018-10-04 | — | — | US | claimed |
| US-11566003-B2 | Isoquinolines as inhibitors of HPK1 | GENENTECH, INC. (US) | 2023-01-31 | — | — | US | disclosed |
| EP-3601259-B1 | ISOQUINOLINES AS INHIBITORS OF HPK1 | HOFFMANN LA ROCHE (CH) | 2022-02-23 | — | — | EP | disclosed |
| US-20210163417-A1 | ISOQUINOLINES AS INHIBITORS OF HPK1 | GENENTECH, INC. (US) | 2021-06-03 | — | — | US | disclosed |
| CN-110709392-A | Isoquinoline as HPK1 inhibitors | 豪夫迈·罗氏有限公司 | 2020-01-17 | — | — | CN | disclosed |
| US-20180282282-A1 | ISOQUINOLINES AS INHIBITORS OF HPK1 | GENENTECH, INC. (US) | 2018-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180282282-A1 | ISOQUINOLINES AS INHIBITORS OF HPK1 | HIPK1, HPGDS, IP6K1 | CHEK1 376/4885KCNH2 3191/4885CHEK2 385/4885 |
| US-11566003-B2 | Isoquinolines as inhibitors of HPK1 | HIPK1, HIPK2, IP6K1 | CHEK1 323/4885KCNH2 3303/4885CHEK2 316/4885 |
| US-20210163417-A1 | ISOQUINOLINES AS INHIBITORS OF HPK1 | HIPK1, HIPK2, IP6K1 | CHEK1 323/4885KCNH2 3303/4885CHEK2 316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.