Bamifylline

Bamifylline

SCHEMBL20522800

CCN(CCO)CCn1c(Cc2ccccc2)nc2c1c(=O)n(C)c(=O)n2C.COP(=O)(NC(C)=O)SC

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
USP2 O75604 1/20 0.46
TSHR P16473 8/20 0.44
LMNA P02545 5/20 0.44
NPSR1 Q6W5P4 3/20 0.44
HTT P42858 3/20 0.44
SMN1; SMN2 Q16637 4/20 0.44
RXFP1 Q9HBX9 1/20 0.44
MAPT P10636 2/20 0.43
TP53 P04637 1/20 0.43
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
GAA P10253 1/20 0.43
JAK2 O60674 1/20 0.42
ALDH1A1 P00352 3/20 0.41
MAPK1 P28482 1/20 0.41
GLA P06280 1/20 0.41
PCSK9 Q8NBP7 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bamifylline SCHEMBL219043 0.85 RXFP1 (0.60) USP2TSHRLMNANPSR1HTT
Bamifylline SCHEMBL637064 0.84 RXFP1 (0.58) USP2TSHRLMNANPSR1HTT
Bamifylline SCHEMBL1648640 0.83 RXFP1 (0.57) USP2TSHRLMNANPSR1HTT
Bamifylline SCHEMBL27460692 0.79 RXFP1 (0.53) USP2TSHRLMNANPSR1HTT
SCHEMBL684310 0.79 RXFP1 (0.66) USP2TSHRLMNANPSR1HTT
Bamifylline SCHEMBL28086377 0.78 TSHR (0.53) USP2TSHRLMNANPSR1HTT
SCHEMBL19829270 0.78 TSHR (0.64) USP2TSHRLMNANPSR1HTT
Bamifylline SCHEMBL28086311 0.72 TSHR (0.44) USP2TSHRLMNANPSR1HTT
SCHEMBL684311 0.72 MLNR (0.53) USP2TSHRLMNANPSR1HTT
SCHEMBL1334308 0.71 ADORA1 (0.57) TSHRLMNANPSR1HTTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11534375-B2 Solvent-free method of encapsulating a hydrophobic active AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2022-12-27 US claimed
US-20200179248-A1 SOLVENT-FREE METHOD OF ENCAPSULATING A HYDROPHOBIC ACTIVE AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2020-06-11 US claimed
WO-2018182509-A1 SOLVENT-FREE METHOD OF ENCAPSULATING A HYDROPHOBIC ACTIVE AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2018-10-04 WO claimed
US-11534375-B2 Solvent-free method of encapsulating a hydrophobic active AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2022-12-27 US disclosed
US-20200179248-A1 SOLVENT-FREE METHOD OF ENCAPSULATING A HYDROPHOBIC ACTIVE AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2020-06-11 US disclosed
WO-2018182509-A1 SOLVENT-FREE METHOD OF ENCAPSULATING A HYDROPHOBIC ACTIVE AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2018-10-04 WO disclosed