Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOD2 | Q9HC29 | 16/20 | 1.00 |
| ▸ | ACVR1 | Q04771 | 16/20 | 1.00 |
| ▸ | RIPK2 | O43353 | 15/20 | 1.00 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.83 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20523489 | 0.91 | NOD2 (1.00) | NOD2ACVR1RIPK2NOD1TGFBR1 | |
| SCHEMBL21630435 | 0.91 | NOD2 (1.00) | NOD2ACVR1RIPK2NOD1TGFBR1 | |
| SCHEMBL20523499 | 0.91 | NOD2 (1.00) | NOD2ACVR1RIPK2NOD1TGFBR1 | |
| SCHEMBL20523451 | 0.90 | NOD2 (0.91) | NOD2ACVR1RIPK2NOD1TGFBR1 | |
| SCHEMBL21630378 | 0.90 | NOD2 (0.81) | NOD2ACVR1RIPK2NOD1TGFBR1 | |
| SCHEMBL20523577 | 0.87 | NOD2 (0.84) | NOD2ACVR1RIPK2NOD1TGFBR1 | |
| SCHEMBL20523447 | 0.87 | NOD2 (1.00) | NOD2ACVR1RIPK2NOD1TGFBR1 | |
| SCHEMBL21630430 | 0.86 | ACVR1 (1.00) | NOD2ACVR1RIPK2NOD1TGFBR1 | |
| SCHEMBL20523618 | 0.84 | NOD2 (0.84) | NOD2ACVR1RIPK2NOD1 | |
| SCHEMBL21630444 | 0.84 | NOD2 (1.00) | NOD2ACVR1RIPK2NOD1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3600307-B1 | COMPOSITIONS FOR USE IN METHODS OF INHIBITING PROTEIN KINASES | UNIV HOUSTON SYSTEM (US) | 2021-05-05 | — | — | EP | disclosed |
| EP-3600307-A1 | COMPOSITIONS FOR USE IN METHODS OF INHIBITING PROTEIN KINASES | University of Houston System (US) | 2020-02-05 | — | — | EP | disclosed |
| WO-2018183633-A1 | COMPOSITIONS FOR USE IN METHODS OF INHIBITING PROTEIN KINASES | UNIVERSITY OF HOUSTON SYSTEM (US) | 2018-10-04 | — | — | WO | disclosed |