Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 11/20 | 0.47 |
| ▸ | FLT3 | P36888 | 3/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 3/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20525624 | 0.93 | MET (0.49) | METFLT3AXLKDR | |
| SCHEMBL20525756 | 0.92 | MET (0.47) | METFLT3AXLKDREGFR | |
| SCHEMBL20525743 | 0.92 | MET (0.51) | METFLT3AXLKDR | |
| SCHEMBL20525853 | 0.91 | MET (0.48) | METFLT3AXLKDR | |
| SCHEMBL20525730 | 0.90 | MET (0.47) | METFLT3AXLKDR | |
| SCHEMBL20525793 | 0.90 | MET (0.50) | METFLT3KDR | |
| SCHEMBL20525761 | 0.90 | MET (0.47) | METFLT3AXLKDREGFR | |
| SCHEMBL20525840 | 0.89 | MET (0.49) | METFLT3KDR | |
| SCHEMBL371701 | 0.89 | MET (0.60) | METFLT3AXLKDREGFR | |
| SCHEMBL20525636 | 0.89 | MET (0.50) | METFLT3AXLKDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-B1 | METHODS OF USING MEK INHIBITORS | EXELIXIS INC (US) | 2018-10-10 | — | — | EP | claimed |